DR THOMAS R. F.RASER ON STROPHANTHTTS HISPIDTJS. 355 



frog was in strong general rigor, with inexcitable, pale, hard, and acid, muscles. The 

 ventricle of the heart was small and pale everywhere except at the apex, and the 

 auricles were dark and large. 



Experiment XXVIII. — In this experiment a relatively large dose, viz., 0*005 grain 

 of strophanthin, was injected in solution under the skin of a frog weighing 375 grains, 

 whose respirations before the injection were 19 per 10 sec. In 15 min., the frog was 

 restless, and the respirations were 25 per 10 sec. and irregular. In 22 min., a constrained 

 posture was assumed, the thoracic extremities being extended, and the chest and head 

 being thereby abnormally elevated. The throat respirations were 13 for 10 sec. and 

 irregular, and only rarely did a thoracic respiratory movement occur. In 32 min., the 

 thoracic extremities had yielded, and the chest was now resting on the table. No 

 thoracic respiratory movements occurred, and those of the throat were only 3 per 10 sec. 

 The mouth was frequently widely opened. In 41 min., respiratory movements ceased, 

 but in the following minute three throat respirations occurred, after which they finally 

 ceased. In 46 min., the frog spontaneously jumped, and then fell on the back, but very 

 soon recovered a normal attitude. In 50 min., another jump was made, and the frog 

 again landed on the back ; and, after turning to the front, the thoracic extremities 

 remained for some time loosely extended at right angles to the body. In 1 hour 27 

 min., the head was resting on the table, and irritation of the skin produced fairly active 

 reflexes in the four limbs, but no attempt to jump. In 2 hours, the frog remained on the 

 back unable to turn. On examination, no cardiac impact could be distinguished; and 

 irritation of the skin was followed by reflexes in the pelvic extremities only, the thoracic 

 extremities being now somewhat rigid. In 2 hours 30 min., the heart was exposed ; it 

 was motionless and non-contractile on irritation, and the ventricle was small and rather 

 pale. In 3 hours 10 min., the muscles of the arms and thighs were exposed ; they were 

 hard, and failed to contract with the strongest interrupted current from a Daniell's 

 cell and Du Bois Keymond's coil, and their reaction was acid. On the following day, 

 general and strong rigor was present, and the auricles of the heart were large and dark 

 and the ventricle was small and pale. No congestion or other abnormal change could 

 be seen in the subcutaneous tissue where the injection had been made. Eigor continued 

 for other two days. The temperature of the laboratory varied between 61° and 64° F. 

 during the whole time of the experiment. 



Experiment XXXII. — In a rabbit weighing 4 lbs. 6 oz., the respirations were 14, 

 and the cardiac impacts 32, per 10 sec, before the injection under the skin of O'Ol grain 

 ( = 0*0022 grain per lb.) of strophanthin. 



After the injection, in 10 min. the respirations were 15, and the cardiac impacts 30, 

 per 10 sec, and the rabbit was restless. In 22 min.. the cardiac impacts were 29 per 

 10 sec. In 34 min., the respirations were 12, and the cardiac impacts 27, per 10 sec. 

 The rabbit was sitting in a normal attitude. In 50 min., the respirations were 17, and 

 the cardiac impacts 30, per 10 sec. In 1 hour 11 min., the rabbit seemed disinclined 

 to go about, but did so well when stimulated; the respirations were 18, and the cardiac 



