356 DR THOMAS R. FRASER ON STROPHANTHUS HISPJDUS. 



impacts 24, per 10 sec. In 1 hour 13 min., the respirations suddenly fell to 6 per 10 sec, 

 and their character became gasping, with laboured inspiration ; and the thoracic 

 extremities were weak, and did not properly support the chest. In 1 hour 16 min., the 

 respiratory rate and characters and the other conditions remained as at last note ; and 

 the cardiac impacts were 28 per 10 sec, strong, but irregular in rhythm. In 1 hour 

 36 min., the respirations were 12, and the cardiac impacts 26, per 10 sec ; and no other 

 symptom was observed than feebleness of the thoracic extremities, and disinclination to 

 move about. On the following day the rabbit was perfectly well. 



Experiment XXXIII. — In a rabbit, weighing 3 lbs., the respirations were 26, and 

 the cardiac impacts 29, per 10 sec, and the pupils were of medium size. 0*01 grain of 

 strophanthin, dissolved in 20 minims of distilled water, was injected under the skin at the 

 right Hank. In 7 min., the rabbit was restless, and the respirations were 21, and the 

 cardiac impacts 29, per 10 sec. In 15 min., restlessness was still manifested, the rabbit 

 sometimes lying down on the abdomen for a few seconds, and then rising and moving 

 about. In 21 min., the respirations were 20, and the cardiac impacts 25, per 10 sec. In 

 31 min., the respirations were 28 per 10 sec and laboured, and the cardiac impacts 29 per 

 10 sec, and stronger than before. The rabbit appeared distressed, and stood with the 

 limbs somewhat extended. In 50 min., the thoracic extremities appeared weak, and the 

 thorax rested on the table. The respirations were 22, and the cardiac impacts 34, per 

 10 sec. A large quantity of urine was passed, and the peristaltic movements of the intes- 

 tines became distinctly visible. In 1 hour 5 min., the rabbit had difficulty in moving 

 about, chiefly due to weakness of the thoracic extremities, and often the head sank 

 gradually, and was suddenly raised. In 1 hour 8 min., the chin rested on the table, 

 the pupils were dilated, and the respirations were 25, and the cardiac impacts 36, per 10 

 sec. In 1 hour 1 min. , one side of the head was frequently rested on the table ; 

 the back was no longer arched ; a general flaccid or limp state existed ; fibrillary twitches 

 occurred over the whole body ; and the respirations were 15, and the cardiac impacts 34, 

 per 10 sec. In 1 hour 13 min., the respirations were 13, and the cardiac impacts 30, 

 per 10 sec, and a little more urine was voided. In 1 hour 14 min., the rabbit was lying 

 on the side entirely flaccid, and remained in any position in which it was placed. The 

 respirations were shallow, and yet laboured and abrupt. In 1 hour 17 min., the 

 respirations were 9, and the cardiac impacts 10, per 10 sec, and the latter were irregular. 

 In 1 hour 20 min., the pupils were dilated, and the cornea and conjunctiva sensitive. 

 The rabbit still lay on the side perfectly flaccid. No cardiac impacts could be felt, but 

 the respirations were 10 per 10 sec, very shallow, abrupt, and irregular. In 1 hour 

 22 min., a few weak twitches of the body and limbs occurred, the eyeballs became 

 prominent (exophthalmos), the pupils dilated further, and the cornea was insensitive. 

 No further respiratory movements occurred. 



After death, at 6 min., the heart having been exposed, the ventricles were found to 

 have ceased contracting except at their bases ; but minute fibrillary twitches were 

 occurring on the surface of each ventricle, and especially of the left, and they continued 



