370 



DR THOMAS R. FRASER ON STROPHANTHUS HISPTDUS. 



normal saline, the following experiments were made, in which this modification was 

 introduced. 



Experiment L. — After the skin had been removed from both pelvic extremities of a 

 pithed frog, the trunk of the sciatic nerve in each extremity was dissected and isolated 

 from the pelvis to the knee, and divided close to the pelvis, and then each leg was 

 amputated immediately above the knee-joint. Two nerve-muscle preparations were thus 

 obtained, A and B, and each was placed in a separate watch-glass containing 0'75 

 per cent, saline, and was tested, in the conditions below noted, by opening shocks from 

 a Drj Bois Reymond's induction apparatus attached to a Daniell's cell, so as to ascertain 

 the minimal shocks required to produce contractions of the muscle. 



A. 







Min. Stimulus re- 









Min. Stimulus re- 









quired to cause Con- 









quired to cause Con- 







Conditions of 



traction of Muscle 







Conditions of 



traction of Muscle 





Time. 



Experiment and 

 Notes. 



when applied to 



Notes. 



Time. 



Experiment and 

 Notes. 



when applied to 



Notes. 



Nerve. 



Muscle. 



Nerve. 



Muscle. 







Mm. of 



Secondary 



Coil. 



Mm. of 



Secondary 



CoiL 









Mm. of 



Secondary 



Coil. 



Mm. of 



Secondary 



Coil. 





2.50 



Both nerve and 

 muscle placed in 

 normal saline. 









2.50 



Both nerve and 

 muscle placed in 

 normal saline. 









2.55 





220 







2.56 





160 







2.57 



Nerve placed in 

 solution of 

 strophanthin, 

 in normal 

 saline 

 (1 :2500). 



















3.4 





220 

















3.30 





240 

















3.45 





260 







3.48 





190 





No spontaneous 



3.50 





260 















fibrillary twitches. 



4.0 





260 

















4.9 



Muscle also 

 placedin above 

 strophanthin 

 solution. 



















4.10 





270 







4.13 





160 





Do. 



4.18 





280 

















4.30 





280 





No spontaneous fi- 

 brillary twitches. 













4.35 





280 





Rarely spontane- 

 ous fibrillary 

 twitches. 













4.40 





260 





Do. 













4.45 





250 





Nearly constant fi- 

 brillary twitches. 













4.50 





260 





Nearly constant fi- 

 brillary twitches. 

 Tested at 170, 

 the contraction 

 is powerful, and 

 relaxation slow. 



4.55 





190 





Do. 



5.0 





260 





Strong, almost 

 constant fibril- 

 lary twitches. 













5.8 





250 

















5.12 





250 

















