DR THOMAS R. FRASER ON STROPHANTHUS HISPIDTJS. 



370 



In this experiment, the nerve-trunk attached to the muscle, which was steeped with 

 its nerve-endings in strophanthin dissolved in normal saline (B), lost its power of 

 stimulating contraction of the muscle in 2 hours and 6 min., although the muscle itself 

 retained its contractility for at least 1 hour and 15 min. longer. That the paralysing 

 action of the nerve is exerted on its terminations and not on its trunk is shown in A, 

 where the nerve-trunk alone was steeped in strophanthin solution, and still retained its 

 conductivity for 3 hours and 23 min. 



Experiment LI I. — Nerve-Muscle Preparations of both Pelvic Extremities of a Frog, 

 prepared in the same way as in Experiment L. 



A. 



B. 







Min. Shocks required 









Min. Shocks required 









to cause Contraction 









to cause Contraction 







Conditions of 



of Muscle when 







Conditions of 



of Muscle when 





Time. 



Experiment and 



, Notes. 



applied to 



Notes. 



Time. 



Experiment and 

 Notes. 



applied to 



Notes. 



Nerve. 



Muscle. 



Nerve. 



Muscle. 







Mm. of 



Mm. of 









Mm. of 



Aim. of 









Secondary 



Secondary 









Secondary 



Secondary 









Coil. 



Coil. 









Coil. 



Coil. 





2.24 



Both nerve and 

 muscle placed 

 in 075 per cent, 

 saline. 









2.24 

 2.35 



Both nerve and 

 muscle placed 

 in "75 per cent, 

 saline. 



330 







2.37 





350 

















2.44 



Both nerve and 

 muscle placed 

 in solution of 

 strophanthin 

 (1:2500). 



















2.46 







210 















2.56 





440 







2.59 





350 







3.5 





440 





No spontaneous 

 fibrillary 

 twitches. 













3.12 









Rarely spontane- 

 ous fibrillary 

 twitches. 













3.15 





370 







3.17 





350 







3.20 





380 





Fibrillary twitches 

 more frequent. 













3.35 





380 







3.36 





390 







3.50 





390 





Fibrillary twitches 

 stronger and 

 more frequent. 



3.54 





380 







4.5 





370 





Do. 



4.12 





380 







4.30 





390 





Fibrillary twitches 

 weaker and less 

 frequent. 













4.50 





390 





Fibrillary twitches 

 very feeble and 

 infrequent. 



5.8 





390 







5.10 





330 

















5.12 





100 





Fibrillary twitches 

 have ceased. 



5.14 





380 







5.15 



No contraction 

 when nerve 

 stimulated, 

 even with the 

 secondary at . 





















5.17 



Do. 





110 















5.20 



Do. 





120 





5.27 





390 







5.40 



Do. 





120 





5.45 







120 





