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DR THOMAS R, FRASER ON STROPHANTHUS HISPIDUS. 



The results are similar to those obtained in the previous experiment. When the 

 muscle with the nerve-endings and the nerve-trunk were placed in saline containing 

 strophanthin (A.), the nerve became paralysed in 2 hours and 31 min., while the muscles 

 continued to respond to direct stimulation for at least 25 min. longer. 



Experiment LIU. — Nerve-Muscle Preparations of both Pelvic Extremities of a Frog, 

 prepared in the same way as in Experiment L. 



A. B. 







Min. Shocks required 

 to cause Contraction 









Min. Shocks required 

 to cause Contraction 







Conditions of 



of Muscle when 







Conditions of 



of Muscle when 





Time. 



Experiment and 

 Notes. 



applied to 



Notes. 



Tlme. 



Experiment and 

 Notes. 



applied to 



Notes. 



Nerve. 



Muscle. 



Nerve. 



Muscle. 







Mm. of 



Secondary 



Coil. 



Mm. of 



Secondary 



Coil. 









Mm. of 



Secondary 



Coil. 



Mm. of 



Secondary 



Coil. 





1.8 



Both nerve and 

 muscle placed 

 in 075 per 

 cent, saline. 









1.8 



Both nerve and 

 muscle placed 

 in 075 per 

 cent, saline. 









1.17 





420 







1.20 





410 







1.25 





420 

















1.27 



Both nerve and 

 muscle placed 

 in solution of 

 strophanthin 



(1 : 5000).' in 

 normal saline. 



















1.40 





410 





Rarely slight 

 spontaneous fi- 

 brillary twitches. 



1.45 





380 







1.55 





440 





Frequent slight 

 spontaneous fi- 

 brillary twitches. 













2.10 





410 







2.12 





430 







2.15 





410 





Rarely slight 

 spontaneous fi- 

 brillary twitches. 













2.25 





410 







2.27 





440 







2.40 





400 





Fibrillary twitches 

 have ceased. 













2.45 







60 





2.47 







180 





2.53 



No contraction 

 when nerve 

 stimulated, 

 even with the 

 secondary 











2.55 





400 







3.16 







60 





3.17 





400 



170 





6.0 







50 





6.5 





380 



140 





On following day, 20 hours after last not 



i, muscle non-con- 



On t 



he following day 









tractile with strongest shocks. Two hours afterwards, the 



at 2.15 P.M., . 



340 



145 





reaction of a cut surface was alkaline. 











In this experiment, when the nerve-trunk and the muscles containing the nerve- 

 endings were placed in strophanthin dissolved in normal saline (A), the nerve became 

 paralysed, abruptly, in 1 hour and 26 min.. while the muscle responded to direct 

 stimulation for at least 3 hours and 7 min. longer. When these structures, removed 



