DR THOMAS E. FEASER ON STROPHANTHUS HISPIDTJS. 



377 



Experiment L V. — For the first experiment two frogs were selected, as similar to each 

 other as possible in weight and general condition. The one, A, weighed 300 grains, and 

 the other, B, 298 grains. To A, curare was administered before Strophanthus, and to B, 

 Strophanthus only was administered. Immediately before the experiment the skin of 

 each frog was moderately dark, and the pupils were of medium size. 



12.32 



2.15 

 2.30 



2.36 



2.41 

 2.45 



2.51 



3.8 



3.25 



3.40 



4.48 



A. Curare before Strophanthus. 



0003 grain of curare in 2 minims of distilled 

 water was injected under the skin of the left 

 flank. 



Frog motionless and flaccid, and no reflexes obtain- 

 able. Cardiac impacts 7 per 10 sec. 



0-01 grain of extract of Strophanthus was injected 

 under the skin of the right flank. 



No fibrillary twitches. Cardiac impacts 7 per 10 sec. 



No fibrillary twitches. Cardiac impacts 7 per 10 sec. 

 No fibrillary twitches. Cardiac impacts 4 per 10 sec. 



No fibrillary twitches. No cardiac impact visible. 



No fibrillary twitches. No cardiac impact visible. 

 The pupils are smaller than before. The skin has 

 become paler. 



No fibrillary twitches. No cardiac impact visible. 

 No reflex movement can be obtained by me- 

 chanical irritation anywhere. 



The right sciatic nerve was exposed and stimulated, 

 but do contraction occurred even with the second- 

 ary at 5 mm. The thigh muscles were exposed : 

 with the secondary at 140 mm., no contraction 

 occurred ; but at 130 mm., the stimulated muscles 

 contracted feebly. 



B. Strophanthus only. 



2.30.30 

 2.35 

 2.37 

 2.38 



2.46 

 2.48 

 2.52 

 2.54 



3.0 



3.5 



3.10 

 3.20 



3.23 

 3.30 



Strongest galvanic stimulation of the trunk of the 

 sciatic nerve produced no effect, but when directly 

 applied to the exposed thigh muscles slight 

 twitches were produced. 



On the following day, at 1 p.m., general rigor was present in both frogs. 



4.10 



4.17 

 4.20 



4.40 



- 01 grain of extract of Strophanthus was injected 

 under the skin of the right flank. 



Active throat and chest respirations. 



Thoracic extremities somewhat extended, 

 lary twitches. 

 Do. Respirations infrequent. 



No fibril- 



No fibrillary twitches. Respirations very feeble and 



infrequent. 

 Rarely weak fibrillary twitches at flanks and back. 



Thoracic extremities still extended. 

 Do. , but twitches more frequent, and also in thighs 



and arms. The respiratory movements have ceased. 

 Thoracic extremities no longer extended. When 



placed on back, remains after a few ineffectual 



efforts to turn. No cardiac impact can be seen. 

 Continuous fibrillary twitches. They occur in the 



four extremities, abdomen, thorax, and head. 



The pupils are contracted. The frog rests on the 



abdomen and thorax. The reflexes are active. 

 The fibrillary twitches are less frequent. The skin is 



pale. 

 Do. The reflexes are feeble. 

 The fibrillary twitches have ceased ; on exposing the 



muscles of the thighs, no twitches are seen. 

 No reflex movement can be obtained by mechanical 



irritation anywhere. 



The right sciatic nerve was exposed : galvanic open- 

 ing shocks, with the secondary at 180 mm., pro- 

 duced no contraction ; at 170 mm., merely a faint 

 twitch of one toe occurred ; and even at 20 mm., 

 merely a faint twitch of two toes occurred, but no 

 reflex contractions. The calf muscles were ex- 

 posed : with the secondary at 60 mm., no con- 

 traction was produced ; at 50 mm., merely a slight 

 depression of the muscle occurred; and no greater 

 effect with the secondary at 2 mm. The pupils 

 are still contracted. 



The strongest galvanism of the sciatic nerve no longer 

 produces any contraction. When the calf muscles 

 were directly stimulated, no effect was produced 

 with the secondary at 40 mm. , and merely a faint 

 depression of the muscle with the secondary at 

 30 mm. 



Strongest galvanic stimulation of the muscle no 

 longer produces any effect. 



The left sciatic nerve and thigh muscles were ex- 

 posed ; strongest galvanic stimulation applied to 

 the trunk of the nerve, or directly to the muscles, 

 failed to produce any effect. 



Cut sections of the thigh muscles were found to be 

 acid in reaction. 



