!80 



DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



Experiment LVII. — continued. 



Jan. 12. 

 1.31 



1.36 



1.45 

 1.46 



1.49 



2.0 



2.25 



2.34 



2.37 



2.52 



.Ian. 13. 



1.5 



Jan. 16. 

 Jan. 17. 

 Jan. 18. 



11 A.M. 



0-1 grain of extract of Strophanthus was injected 

 under the skin of the two thighs. 



Ventricular contractions have ceased, and the ven- 

 tricle is pale ami contracted. Auricular contrac- 

 tions, 11 per 30 sec, and feeble. 



Auricular contractions have ceased. 



The frog jumps about actively. 



The thoracic extremities are a little stiff, though 

 still mobile. The frog can no longer jump, but it 

 pushes itself about by vigorous movements of the 

 pelvic extremities. 



The thoracic extremities are very stiff. Irritation 

 produces pretty active reflex movements of the 

 pelvic extremities. Respiratory movements have 

 ceased. Fibrillary twitches occur at the lower 

 part of the abdomen. 



Irritation of the skin produces no reflex movement 

 unless it be powerful, when strong movements 

 are slowly produced in the pelvic extremities. 



The pelvic extremities are now somewhat stiff, and 

 when the skin is irritated very sluggish and 

 feeble reflex movements occur in them. The 

 fibrillary twitches have ceased. 



Strong galvanic stimulation applied to any part of 

 the skin produces no effect, except when it is 

 applied to one of the feet, when feeble movements 

 occur which are restricted to the parts through 

 which the galvanic current has been passed. 

 Galvanic stimulation applied to the exposed left 

 sciatic nerve produces feeble movements below 

 the left knee, but no reflex contractions. 



Strong galvanic stimulation applied to the exposed 

 sciatic nerve produces no contraction ; when 

 applied to exposed muscles in the left thigh and 

 calf, no movement occurs. 



General rigor is present everywhere, and the muscles 

 are pale, hard, and acid. The heart's ventricle 

 is pale and rigid. 



Do. do. 



Do. do. 



The muscles are now softer. The heart's ventricle 

 is less rigid, and in several places dark patches 

 are seen. 



Jan. 12. 

 1.33 

 1.35 



1.45 

 1.48 



1.50 

 1.57 



2.10 

 2.30 



2.35 



3.0 

 4.15 



Jan. 13, 

 1.0 P.M. 



B. 



Mouth frequently opened widely. Respirations in- 

 terrupted by long intervals, during which none 

 occur. 



Prolonged cessation of respiration. 



Gaping movements following series of a few feeble 

 respirations. 



Mouth kept widely open for a long time, then the 

 frog jumped, and afterwards mouth was shut, 

 and a number of strong thoracic respiratory move- 

 ments occurred, and were followed by numerous 

 feeble throat respirations. 



The frog jumps about actively. Long respiratory 

 pauses alternating with two or three laboured re- 

 spirations. 



Do. do. Occasional laboured respirations. 



The frog continues to jump about actively. 



The frog jumps only feebly when irritated. Active 

 spontaneous movements, however, still occur. 



The frog jumps spontaneously. 



The frog cannot jump, but it pushes itself about by 

 vigorous movements of the four extremities. 



The frog has for some time been lying on the abilo 

 men and thorax. Irritation causes well-marked 

 reflex movements. 



Irritation no longer excites reflex movements. Gal- 

 vanic stimulation of an exposed sciatic nerve 

 causes only feeble movements of the limb sup- 

 plied by the nerve ; but when directly applied tu 

 exposed muscles, it causes strong contractions in 

 them. The body and limbs are perfectly flaccid. 



