DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 385 



afterwards in extract of Strophanthus dissolved in 06 per cent, saline, 1 : 25,000. The 

 muscle only was stimulated (Plate VIII.). 



2.8. Muscle fixed in myograph, and immersed in - 6 per cent, saline. 



2.15 to 2.17. Several tracings taken with the secondary coil at 70 mm. 



2.17. Tracing No. 1. Secondary at 70 mm. 



2.18. Solution of Strophanthus extract, 1 : 25,000, substituted for simple saline. 

 2.20 to 6.58. Numerous tracings taken : — 



2.45 to 5.17. Spontaneous fibrillary twitches were occurring in the muscle. They were frequently 

 strong, and were nearly continuous between 3.15 and 4.53. During the periods of the strongest 

 and unceasing twitches, stimulation failed to excite any contraction of the muscle, but it produced 

 a restricted contraction during the intervals when the muscle was relatively quiescent. At 4. 20, 

 during the period of strongest twitches, the muscle did not contract with the secondary coil at 

 30 mm.; but at 5.33, after the twitches had ceased, it contracted with the secondary at 60 mm., 

 and continued to do so with the latter stimulus until the termination of the Experiment (6.58). 



3.10. Tracing No. 2. Secondary at 70 mm. The descending line shows numerous short curves produced 

 by the commencing fibrillary twitches. 



3.35. Tracing No. 3. Secondary at 70 mm. Taken during an interval of muscle quiescence. 



3.40. Tracing No. 4. Do. Muscle stimulated during a period of active spontaneous 



twitches. 



4.13. Tracing No. 5. Do. Do. 

 4.27. Tracing No. 6. Secondary at 30 mm. 



4.47. Tracing No. 7. Do. Marked secondary rise of muscle curve. 



5.40. Tracing No. 8. Do. Only slight secondary rise of muscle curve. 



Experiment LXII. — Gastrocnemius muscle placed in 0'6 per cent, saline, and after- 

 wards in extract of Strophanthus dissolved in saline, 1 : 2500. Nerve and muscle 

 stimulated separately (Plate IX.). 



1.32. Muscle fixed in myograph and immersed in 06 per cent, saline. 



1.52 to 1.54. Several tracings taken with the secondary coil at 80 to 100 mm. 



1.49. Tracing No. 1. Nerve stimulation ; secondary at 200 mm. 



1.54. Tracing No. 2. Muscle stimulation ; secondary at 80 mm. 



1.58. Solution of Strophanthus extract, 1 : 2500, substituted for simple saline. 



2.9 to 5.45. Numerous tracings taken in which the nerve and muscle were stimulated separately : — 



2. 10 to 3.35. Spontaneous fibrillary twitches occurred in the muscle, which were very strong and nearly 

 unceasing between 2.20 and 3.0. During the period of strongest continuous twitchings, galvanic 

 stimulation of either the nerve or the muscle failed to excite any contraction, but it succeeded 

 in doing so in intervals of comparative quiescence, and, also, after the twitches had ceased. 

 Very soon after the disappearance of spontaneous twitches, stimulation of the nerve, even 

 with the secondary coil at 0, failed to excite any contraction of the muscle, whereas direct 

 stimulation of the muscle succeeded in doing so for a long time afterwards. At 2.30, the 

 muscle no longer responded to a stimulus of 80 mm., but did so to one of 60 mm. 



2.10. Tracing No. 3. Muscle stimulation, with secondary at 80 mm. 



2.20, Tracing No. 4. Curves produced by spontaneous fibrillary twitches. 



2.24. Tracing No. 5. Do. 



2.29. Tracing No. 6. Do. 



2.34. Tracing No. 7. Do. 



2.49. Tracing No. 8. Curves produced by spontaneous fibrillary twitches, with a contraction caused by 



nerve stimulation. Secondary, 200 mm. 



2.50. Tracing No. 9. Do., with a contraction caused by muscle stimulation. Secondary, 80 mm. 



3.14. Tracing No. 10. Do. do. 



