386 DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



3.41. TracingNo.il. Muscle stimulation ; secondary, 60 mm. Spontaneous twitches have ceased. The 



strongest galvanic stimulation applied to the nerve, fails to excite any contraction. 



3.57. Tracing No. 12. Muscle stimulation ; secondary at 60 mm. 



4.19. Tracing No. 13. Do. secondary at 30 mm. 



5.2. Tracing No. 14. Do. secondary at 40 mm. 



5.5. Tracing No. 15. Do. secondary at 50 mm. 



5.15. Tracing No. 16. Do. secondary at 60 mm. 



Experiment LXIII. — Gastrocnemius muscle placed in 0'6 per cent, saline, and 

 afterwards in extract of Strophanthus dissolved in 0"6 per cent, saline, 1:2000. The 

 muscle only was stimulated (Plate X.). 



1.48. Muscle fixed in myograph, and immersed in 0'6 per cent, saline. 



1.50 to 1.57. Several tracings taken with the secondary coil at 50 to 60 mm. 



1.57. Tracing No. 1. Secondary at 50 mm. 



2.O. Solution of Strophanthus extract, 1 : 2000, substituted for simple saline. 



2.12 to 10.0. Numerous tracings taken : — 



2.4 to 3.13. Spontaneous fibrillary twitches occurred, which were strong and frequent between 2.22 



and 2.40 ; but stimulated contractions of the muscle were followed by a few twitches, even 



at 4,48 (see Tracing No. 2). After the twitches had nearly ceased, the muscle continued to 



respond to a stimulus of 50 mm. until 10.0. 

 4.48. Tracing No. 2. Secondary at 30 mm. Fibrillary twitches started by stimulation of muscle. 

 5.10. Tracing No. 3. Secondary at 50 mm. Great prolongation of the stimulated contraction. 

 5.40. Tracing No. 4. Do. Great prolongation of the stimulated contraction, with slow 



attainment of the maximum contraction, and gradual relaxation. 



6.0. Tracing No. 5. Do. do. 



6.40. Tracing No. 6. Do. do. 



8.50. Tracing No. 7. Do. do. 



10.0. Tracing No. 8. Do. do. 



Experiment LXIV. — Gastrocnemius muscle placed in 0.6 per cent, saline, and 

 afterwards in extract of Strophanthus dissolved in 0'6 per cent, saline, 1 : 2000. The 

 muscle only was stimulated (Plate XL). 



1.10. Muscle fixed in myograph, and immersed in - 6 per cent, saline. 



1.20 to 1 24. Several tracings taken with the secondary coil at 60 mm. 



1.24. Tracing No. 1. Secondary at 60 mm. 



1.26. Solution of Strophanthus extract, 1:2000, substituted for simple saline. 



1.37 to 5.26. Numerous tracings taken : — 



1.35 to 2.50. Spontaneous fibrillary twitches occurred, which were strong and nearly continuous 



between 1.41 and 2.12. Except during strong twitches, the muscle continued to respond well to 



a stimulus of 60 mm., until 3.12. 

 1.41. Tracing No. 2. Secondary, 60 mm. Muscle stimulated during fibrillary twitches. 



1.50. Tracing No 3 

 2.0. Tracing No. 4 

 2.25. Tracing No. 5 

 2.36. Tracing No. 6 

 3.42 Tracing No. 7 



3.51. Tracing No. 8 

 4.32. Tracing No. 9 



Do. do. 



Curves produced by spontaneous fibrillary twitches. 



Secondary, 60 mm. Muscle stimulated during fibrillary twitches. 



Secondary, 60 mm. 



Secondary, 30 mm. 



Secondary, 50 mm. 



Secondary, 20 mm. 



• r ). 2 1 . Tracing No. 1 0. Secondary, 20 mm. 



