

the muscle. 





6.22. 



Tracing No. 3. 



Secondary at 60 mm. 



6.35. 



Tracing No. 4. 



Do. 



8.7. 



Tracing No. 5. 



Do. 



DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 387 



Experiment LXV. — Gastrocnemius muscle placed in 0*6 per cent, saline, and after- 

 wards in extract of Strophanthus dissolved in 0*6 per cent, saline, 1 : 25,000. The 

 muscle only was stimulated (Plate XII.). 



4.5. Muscle fixed in myograph, and immersed in 0"6 per cent, saline. 



4.19 to 4.25. Several tracings taken with the secondary coil at 90 mm. 



4.22. Tracing No. 1. Secondary, 90 mm. 



4.27. Solution of extract of Strophanthus in saline, 1:25,000, substituted for simple saline. 



4.33 to 8.7. Numerous tracings taken : — 



4.42 to 6.18. Spontaneous fibrillary twitches occurred, which were moderately strong between 5.15 

 and 6.0. The muscle ceased to respond to a stimulus of 90 mm. at 4.36, but thereafter responded 

 well to one of 60 mm., except when the twitches were strong and nearly continuous, when, 

 sometimes, even a stimulus with the secondary at failed to excite any contraction. 



5.43. Tracing No. 2. Secondary at 60 mm. Fibrillary twitches excited by the stimulated contraction of 



Slow relaxation following a good contraction, 

 do. 

 do. 



Only a few experiments were made with strophanthin itself, and the phenomena 

 described and represented in the preceding experiments were reproduced in them. The 

 delay in muscular relaxation only has been represented in the tracings illustrative of the 

 next experiment. 



Experiment LXVI. — Gastrocnemius muscle placed in # 6 per cent, saline, and after- 

 wards in strophanthin dissolved in 0'6 per cent, saline, 1:20,000. Both nerve and 

 muscle were stimulated (Plate XII.). 



12.46. Muscle fixed in myograph, and immersed in 0-6 per cent, saline. 

 1.5 to 1.16. Several tracings taken. 



1.16. Tracing No. 1 ; muscle stimulation; secondary at 50 mm. 

 1.19. Solution of strophanthin, 1 : 20,000, substituted for simple saline. 

 1.33 to 4.41. Numerous tracings were taken, in which the nerve and muscle were separately stimulated : — 

 2.10 to 2.31. Spontaneous fibrillary twitches occurred in the muscle. Stimulation of the nerve at 



1.12 produced a good contraction with the secondary coil at 200 mm. ; from 2.8 to 2.29 it produced 



only a feeble contraction with the secondary at 170 ; and at 2.31 it altogether failed to produce 



any contraction, even when the secondary was at 0. 

 3.18. Tracing No. 2. Muscle stimulation; secondary at 50 mm. Greater part of relaxation fairly 



normal, but latter part very slow. 

 4.41. Tracing No. 3. Muscle stimulation ; secondary at 30 mm. Do. 



