DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 393 



11.34 a.m. The brain was destroyed, and the frog secured on its back. 



11.40. Heart exposed, and the pericardium cut, and drawn ofE the front of the heart. 



11.45. Heart's contractions 22 per 30 sec. Ventricular systole deliberate, but at its completion the 



ventricle is only moderately pale ; diastole is abrupt and complete. 

 11.47. Heart's contraction 22 per 30 sec. Do. 



11.50. Placed on the heart 2 minims of a solution of 0'05 grain of strophanthin in 100 minims of - 6 per 



cent, of saline ( = - 001 grain). 



11.51. Heart's contractions 22 per 30 sec. 



11.53. Heart's contractions 21 per 30 sec. During systole, the ventricle becomes paler than before. 

 11.57. Heart's contractions 20 per 30 sec. Diastole of ventricle still abrupt. 



11.59. Heart's contractions 18 per 30 sec. Ventricular systole longer than before ; diastole less complete. 



12.2. Heart's contractions 15 per 30 sec. ; diastole markedly less complete ; auricles distended. 



12.4. Only slight dilatation of ventricle during diastole. Heart contracts irregularly. 



12.5. Heart's contractions 12 per 30 sec. Ventricle small and pale, and almost no movement during 



either systole or diastole ; auricles distended, and their movements ample. Frequent struggles. 

 12.7. Ventricle motionless in systole ; auricles contract 18 per 30 sec. Frequent struggles. 

 12.10. Ventricle motionless in extreme systole; auricles contract 18 per 30 sec, but the contractions are 



mainly in the left auricle. 

 12.12. Do. ; the left auricle, and mainly its left upper portion, contracts 5 per 30 sec, the right auricle 



being motionless. 

 12.14. Do. ; left auricle feebly twitches, 9 times in 30 sec 



12.17. No spontaneous movement of any part of heart. Frequent struggles. 



12.31. Do. do. Mechanical irritation of the ventricle and auricles produces no effect. The auricles 



are dark and large, and the ventricle is small and very pale. Occasional weak struggles. 

 12.37. General reflex movements can be excited on slight irritation of any part of the skin. 

 12.57. Reflex movements can no longer be excited. 

 3.0. Do. Irritation of an exposed sciatic nerve is followed by movements of the limb supplied by it. 

 With the exception of the ventricle of the heart, all parts of the frog are perfectly flaccid. 



Experiment LXXVI. — In this experiment the frog weighed 542 grains, and the 



dose of strophanthin applied to the heart was 0*0005 grain ( = 0'000092 grain per 100 



grains). 



11.35. The brain was destroyed, and the frog tied down on its back. 

 11.39. Heart exposed, but pericardium not removed from its surface. 



11.44. Heart's contractions 26 per 30 sec. Ventricular systole good, but when complete the ventricle is 

 only moderately pale ; diastolic movement abrupt. 



11.52. Heart's contractions 25 per 30 sec. 



11.54. Applied to surface of heart 1 minim of solution of 0"05 grain strophanthin in 100 minims of 



- 6 per cent, saline ( = 0'0005 grain). 

 11.55 and 11.58. Heart's contractions 25 per 30 sec. 



12.2. Heart's contractions 24 per 30 sec. Both systolic and diastolic movements seem larger. 

 12.9. Heart's contractions 24 per 30 sec. Dilatation of ventricle rather less during diastole. 

 12.14. Heart's contractions 20 per 30 sec. Ventricular systole decidedly prolonged. 



12.18. Heart's contractions 17 per 30 sec. 



12.19. Heart's contractions 14 per 30 sec; slightly irregular, and occasionally a short pause in extreme 



ventricular diastole. 



12.21. Heart's contractions 5 per 30 sec. Distinct pauses in extreme ventricular diastole; systole very 

 complete, with small and nearly white ventricle at its termination. 



12.23. Heart's contractions 5 per 30 sec. Pause in diastole of ventricle about 7 sec, the systolic move- 

 ment occupying about 3 sec. Occasional respiratory movements of throat. 



12.25. Do. do. 



