'394 DR THOMAS R. FRASER ON STROPHANTHTJS HISPIDUS. 



12.33. Heart's contractions 6 per 60 sec; slightly irregular ; diastolic pause about 12 sec, sometimes 



9 sec. 

 12.41. Heart stopped in extreme ventricular diastole for a little more than 3 min. ; auricles not much 



distended. 



12.43. A drop of saline placed on heart caused a single contraction, followed by rest in moderate diastole. 



12.44. Heart contracting spontaneously at rate of 12 per 30 sec; then stopped in moderate diastole; 



and during pause frequent throat respirations. 

 12.48. Contractions spontaneously resumed, and continued for 45 sec, during which time 23 good con- 

 tractions occurred, now without much increase in period of ventricular diastole ; and, then, pause 

 in moderate systole. Auricles are not distended. 



12.45. No contraction of heart since last note. The ventricle is small and moderately pale. Rare throat 



respirations. 

 12.55. Contractions of heart spontaneously resumed for 1 min. at the rate of 12 per 30 sec; and 



they then ceased, when the ventricle was small and very pale. During the contractions, the 



ventricular diastole was very slight, the ventricle remaining always pale. The auricles are now 



larger than before. 

 1.0. Do., with pause of ventricle for 40 sec. Do. 

 1.6. Do. 

 1.20. No contraction of heart since last note. The ventricle is small and very pale, the auricles are 



somewhat large and dark. No respiratory movements. Irritation of skin caused strong general 



movements, but no movement of the heart occurred during them. 

 1.30. No contraction of heart since 1.8. Ventricle pale and very small, auricles dark and distended. 



A drop of saline was placed on the heart, and the ventricle and auricles were separately and 



strongly irritated with the point of a scalpel, without movement following in any part of the 



heart. General reflex movements were easily excited. 

 1.55. Sections of the excised ventricle were found to have an acid reaction. 



Experiment LXXVII. — The frog in this experiment weighed 666 grains, and the 

 dose of strophanthin was 0*000625 grain ( = 0*0000938 per 100 grains). 



2.23 p.m. The brain was destroyed. 

 2.26. Heart exposed, and pericardium removed. 



2.29. Heart's contractions 17 per 30 sec. Diastole brief and abrupt, systole longer than diastole, but ven- 

 tricle only slightly pale in extreme systole. 



2.31. Heart's contractions 17 per 30 sec. Do. 



2.32. Heart's contractions 18 per 30 sec. Do. 



2.34. Applied to surface of heart \\ minims of solution of - 05 grain of strophanthin in 100 minims of 



0"6 per cent, saline ( = - 000625 grain). 

 2.36. Heart's contractions 18 per 30 sec. Diastole brief and abrupt, systole longer, and ventricle becomes 



only slightly pale. 

 2.38 to 2.41. Do. do. 



2.43 to 2.45. Heart's contractions 17 per 30 sec. Do. 



2.46 to 2.48. Heart's contractions 16 per 30 sec. Do. 



2.50 to 3.0. Heart's contractions 14 per 30 sec, systole decidedly longer, and during it the ventricle 



becomes paler and a little smaller than before. 

 3.4. Heart's contractions 14 per 30 sec. Ventricular diastole interrupted by pause on contraction of 



auricles and before completion of ventricular diastole. 

 3.7 to 3.16. Heart's contractions 13 per 30 sec. Both systole and diastole of ventricle very complete, 



and in systole the ventricle becomes paler than before. 

 3.18 to 3.38. Heart's contractions 12 per 30 sec. ; the pause before completion of diastole has latterly 



been more marked. Observations interrupted until 



