396 DR THOMAS R. FRASER ON STROPHANTHUS HISPIDTTS. 



J:\rpenment LXXVI1I. — Frog 556 grains in weight. 0*0005 grain of strophanthin 

 applied to the surface of the heart ( = "00008 9 grain per 100 grains). 



11.31a.m. Brain destroyed. 



11.36. Completed exposure of heart. 



11.38 to 11.40. Heart's contractions 18 per 30 sec. 



11.42. Applied to the surface of the heart 1 minim of a solution of 0'05 grain of strophanthin in 100 



minims - 6 per cent, saline ( = 0-0005 grain). 

 11.44 to 11.56. Heart's contractions 18 per 30 sec. 

 11.57. Heart's contractions 18 per 30 sec. Systole seems stronger. 

 11.59 and 12.0. Do. do. 



12.3. Heart's contractions 14 per 30 sec. Diastole seems greater, and is more slowly attained than 



before. 



12.4. Heart's contractions 12 per 30 sec. Slight pause in extreme diastole. 



12.6. Heart's contractions 12 per 30 sec. Both systole and diastole seem increased. Diastole is inter- 

 rupted, and consists, first, of dilatation with moderate darkening, and then, after a faint pause, 

 of further dilatation and darkening, immediately succeeding contraction of the auricles. 



12.8 to 12.17. Heart's contractions 14 per 30 sec. The pause during diastole has disappeared. 



12.21. Heart's contractions 12 per 30 sec. Peristaltic movements occur involving the whole heart. 



12.24 to 12.26. Heart's contractions are not synchronous ; 2 auricular contractions occur to 1 ventricular, 

 and in the pause the ventricle is in extreme diastole. Ventricular systole is powerful. 



12.28. Fifteen auricular contractions to 1 ventricular contraction per 60 sec. Ventricle very large and 



dark during standstill. 



12.29. Some general struggles, immediately succeeded by a number of synchronous heart's contractions. 

 12.30 to 12.32. The ventricle is motionless in extreme diastole. Auricular contractions 12 per 30 sec. 

 12.32.30. Heart's contractions spontaneously became again synchronous at rate of 8 per 30 sec. After 



a minute, the pauses in extreme ventricular diastole become longer, and then the ventricle 

 ceased to contract ; after 4 contractions of the auricles, the whole heart remained motionless 

 in diastole for 3 min. 

 12.36. Nine synchronous contractions spontaneously occurred ; then 2 contractions of the auricles (the 

 first strong, the second very feeble), and the whole heart again became motionless in extreme 

 diastole for 2 min. 

 Irregularities of a similar kind, with, invariably, standstill in extreme ventricular diastole, con- 

 tinued to occur till 12.59. 



1.0. Heart's contractions were limited to the auricles, which contracted at rate of 2 per 60 sec, and the 

 ventricle was motionless in extreme diastole. Occasionally respirations occur. 



1.3. General struggles, followed by a few synchronous contractions of the heart. 



1.5. Ventricle motionless in extreme diastole ; rarely a feeble auricular contraction. 



1.8. Do. do. 



2.30. Heart motionless. Ventricle large, but not quite so dark in colour as at 1.8. Irritation of any 

 part of the heart fails to excite contraction. General reflex excitability has disappeared. 



In the preceding four experiments, the heart was brought to a standstill in systole, 

 in the experiment (LXXV.) in which the largest dose of Strophanthus was applied to its 

 surface ; systolic and diastolic exaggeration were both displayed in the experiment 

 (LXVI.) in which a rather smaller dose was applied, but systole ultimately prevailed, 

 and, when brought to a standstill, the heart's ventricle was small and pale ; while in the 

 two latter experiments (LXXVIL and LXXVIIL), in which the doses were the smallest, 

 ventricular diastole greatly predominated throughout, and the heart frequently paused 



