398 DR THOMAS E. FRASER ON STROPHANTHUS HISPIDUS. 



4.26. Lowest portion of curve has fallen to the abscissa-line ; the drum was slightly lowered. 

 4.38. Third application of strophanthin solution, £ minim ( = 0-00025 grain). 



4.49. Tracing No. 3. The ventricle is much larger than before, and diastole is much increased. 



5.20. Fourth application of strophanthin solution, 1 minim ( = 0-0005 grain). 



5.24. Tracing No. 4. The curve has risen further above the abscissa-line. 



5.35. Tracing No. 5. 



5.42. Fifth application of strophanthin solution, 1 minim ( = 0-0005 grain). 



5.46. Tracing No. 6. 



6.7. Sixth application of strophanthin solution, 1 minim ( = 0-0005 grain). 



6.33. Seventh application of strophanthin solution, 1 minim ( = 0-0005 grain). 



6.40. Tracing No. 7. 



7.3. Eighth application of strophanthin solution, 2 minim ( = 0-001 grain). 

 7.10. Tracing No. 8. The curve has risen still further above the abscissa-line. 

 7.13. Tracing No. 9. 



7.18. The curve has risen much above the abscissa-line. 



7.24. Tracing No. 10. The larger curve corresponds with the contraction of the auricles. Almost no 

 ventricular systole — only a slight ventricular impulse follows the propulsion of a little blood 

 into the ventricle from the auricles, and is represented by the second of the two curves. Only a 

 small part of the ventricles dilates. 



7.32. Tracing No. 11. Do. do. The ventricle is small, and nearly the whole of it is continuously pale. 



The tracings in this experiment show, in the first place, considerable increase in the 

 movements of the ventricle, the diastolic expansion being large, and the systolic con- 

 traction very complete. Soon, however, the ventricular movements became diminished 

 by an exaggeration of the systolic condition, which increased so that very little ventricular 

 expansion occurred in the period of diastole, and long pauses took place in extreme 

 ventricular systole. Even in the last tracing, when the ventricle is almost motionless, 

 the auricular movements continued to be fairly large. (Plate XIII., tracing 11, a.) 



Experiment LXXX. — Weight of frog {Rana esculenta), 1082 grains. 0'0025 grain 

 of strophanthin in 0'05 per cent, solution ( = 0"00023 grain per 100 grains) applied to 

 the heart in divided doses during 3 hours 17 min. (Plate XIV.) 



1.30 a.m. Frog pithed. 

 3.40. Cardiograph applied. 



3.43. Tracing No. 1. 



3.47. Applied to the heart -| minim ( = 0-00025 grain) of above strophanthin solution. 



4.27. Second application of strophanthin solution, | minim ( = 0-00025 grain). 



4.29. Lowest portion of cardiograph curve has fallen to the abscissa-line ; readjusted the lever. 



4.40. Tracing No. 2. 



4.42. Third application of strophanthin solution, 1£ minims ( = 0*00075 grain). 



4.45. Frequent fibrillary twitches of muscles of thorax and abdomen. 



4.55. Tracing No. 3. Cardiograph curve has risen above abscissa-line. First portion of ascending line 



of curve corresponds with contraction of the auricles, which is now much increased. 

 5.5. Tracing No. 4. 

 5.29. Tracing No. 5. First portion of ascending line of curve corresponds with auricular contraction. 



5.56. Fourth application of strophanthin solution, 1 minim ( = 00005 grain). 



6.0. Tracing No. 6. Great increase of both auricular and ventricular contraction, and also of 

 ventricular dilatation. 



6.4. Fifth application of strophanthin solution, 1 minim ( = 0-0005 grain). 



