DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 399 



6.26. Tracing No. 7. First portion of ascending line indicates dilatation of the ventricle caused by- 

 contraction of the auricles. The beginning of ventricular systole corresponds with the second 

 portion. Long pause in ventricular diastole. Both systole and diastole are exaggerated. 



6.43. Sixth application of strophanthin solution, 1 minim ( = 0-0005 grain). 



7.2. Tracing No. 8. See note at 6.26. 



7.4. Seventh application of strophanthin solution, \ minim ( = 0-00025 grain). 



7.17. Tracing No. 9. See note at 6.26. 



7.25. Tracing No. 10. Do. 



7.50. Tracing No. 11. Do. 



The cardiograph was removed from the heart, and the frog put aside until the following morning, when, at 



11.30 a.m. The heart was motionless, with the exception of the left auricle, where faint spontaneous 

 movements were occurring at long intervals. The ventricle was moderately dark and dilated. 



3.0 p.m. The ventricle is still motionless, but it is much smaller and much paler than at 11.30. The 

 auricles have become larger and darker, and they also are motionless. 



In this experiment also, at first, there was shown considerable increase of ventricular 

 movement, with exaggeration of systole. Bye and bye, both the ventricular and auricular 

 movements were together increased, the increase of the latter being very great for a long 

 period. Later, ventricular systole predominated over diastole, although, for some time 

 during the experiment, ventricular diastole was the predominating condition. 



Experiment LXXXI. — Weight of frog (Rana esculenta), 1310 grains. 0*001 grain 

 of strophanthin in 0'05 per cent, solution ( = 0'0000763 grain per 100 grains) applied to 

 the heart in two doses of 0'0005 grain each, separated by an interval of 25 min. 

 (Plate XV.). 



1.15 p.m. Frog pithed. 



On the following day, at 



12.15. Cardiograph applied. 



12.20. Tracing No. 1. Heart's contractions very feeble. 



12.26. Applied to heart 1 minim ( = 0-0005 grain) of above strophanthin solution. 

 12.26.40. The curve has fallen nearer to abscissa-line. 



12.40. Tracing No. 2. First curve corresponds with contraction of the auricles; the second with con- 

 traction of the ventricle. 

 12,51. Second application of strophanthin solution, 1 minim ( = 0-0005 grain). 

 12.53. Tracing No. 3. 

 1.15. Tracing No. 4. 

 1.33. Tracing No. 5. Contractions of the heart irregular in character, bijeminal, the ventricular systoles 



being alternately weak and powerful. 

 1.45. Tracing No. 6. Do., to even a more marked degree. 

 1.52. Tracing No. 7. Contractions again regular, with much increase both of systole and diastole of 



ventricle. 

 2.2. Tracing No. 8. Do., ventricular systole less powerful. The curve has fallen nearer abscissa-line. 

 2.25. Tracing No. 9. Great increase of condition of systole in ventricle. The curve has risen. 

 2.32. Tracing No. 10. Do. do. Still further rise of curve from abscissa-line. Greater dilatation of 



ventricle and auricles. 

 2.40. Curve again fell, and as it soon reached the abscissa-line, a readjustment of the lever was required. 

 2.45. Tracing No. 11. Contractions of heart, arhythmical, two auricular contractions occurring for one 

 ventricular contraction. 

 VOL. XXXVI. PART II. (NO. 16). 3 P 



