Ills DR THOMAS R. FRASER ON STROPHANTI! US HTSPIDTJS. 



before strophanthin had been applied. Soon, standstill again occurred for 3 min. in extreme 

 ventricular diastole ; then a single contraction, followed by standstill in extreme diastole for a 

 minute and a half ; then a single strong contraction followed by diastolic standstill for a minute 

 and a half ; and then 7 contractions during 45 sec. again followed by a long pause in extreme 

 ventricular diastole. This irregular action continued until 3.23, the pauses being invariably in 

 extreme ventricular diastole, and the systolic contractions of the ventricle being usually powerful. 



3.24. At the end of a long pause, strong general struggles occurred ; and during this, and for a brief period 

 subsequently, the heart contracted rapidly. A long pause again occurred, and again struggles 

 with a brief resumption of the heart's contractions took place; and this was several times repeated. 



3.41 to 5.19. Heart's contractions vary from 4 to 7 per 30 sec, the pauses are in extreme diastole, but 

 the ventricular systoles are powerful. 



5.20. Applied to surface of heart 05 minim of solution of - 05 grain of strophanthin in 100 minims 

 ( = 0-00025 grain). 



5.22 to 7.45. Heart's contraction much as described from 2.47 to 3.23, with similar irregularities, and 

 with pauses of from 7 sec. to 4 min. duration, with the ventricle in extreme diastole. 



On the following clay, at 



5.30 p.m. The heart was contracting regularly and synchronously, at the rate of 9 per 30 sec, and there 

 was no evident exaggeration of either systole or diastole. Two minims of strophanthin solu- 

 tion (0'05 grain in 100 minims) were applied to the heart's surface; and at 7.15 p.m., the 

 heart was motionless, with the ventricle small and pale. 



Experiment CXI. — Weight of frog, 410 grains. 0'003 grain, and afterwards 0'004 

 grain, of sulphate of atropine applied to the heart before '000 6 2 grain of strophanthin. 



2.38. Brain destroyed. 



2.40. Heart exposed, and pericardium removed. 



2.44 to 2.47. Heart's contractions 16 per 30 sec. 



2.48. Applied to surface of heart - 003 grain of sulphate of atropine in 0"2 per cent, solution. 



2.51 to 3.1. Heart's contractions 16 per 30 sec. 



3.4. Applied to surface of heart - 004 grain of sulphate of atropine in 0"2 per cent, solution. 



3.6 and 3.8. Heart's contractions 16 per 30 sec. 



3.9. Applied to surface of heart 1^ minim of solution of - 05 grain of strophanthin in 100 minims 



( = 0-00062 grain). 

 3.12 to 3.16. Heart's contractions 16 per 30 sec. 

 3. 1 8. Heart's contractions 1 5 per 30 sec. Ventricular systole appears slightly longer than before ; 



diastole abrupt and without interruption. 

 3.26 to 3.29. Heart's contractions 13 per 30 sec. 

 3.32. Heart's contractions 12 per 30 sec, both systole and diastole good, but with slight interruption 



towards end of diastole. 



3.39. Heart's contractions 11 per 30 sec. Distinct pause during ventricular diastole before complete 



dilatation by contraction of auricles. 



3.41 to 3.58. Heart's contractions 10 per 30 sec. Ventricular systole is rather longer than the diastole. 



4.0 to 4.8. Heart's contractions 8 per 30 sec Pauses in extreme diastole of the ventricle, for from 2 to 

 6 sec. The pause is before auricular contraction, which increases the amount of ventricular 

 dilatation, and is immediately followed by a strong and complete contraction of the ventricle, 

 after which the ventricle slowly dilates. 



4.13. Heart's contractions 6 per 30 sec. Do. do. 



4.16. Complete standstill of the heart for 12 min., with very large and dark ventricle, and moderately 

 large auricles. A drop of saline applied to the heart did not excite any movement. Pinching 

 a foot caused some struggles, when a single contraction of the whole heart occurred, and was 

 followed by complete standstill with extreme ventricular diastole for 7 min. The observations 

 were now interrupted until 



