410 DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



Laro-e doses caused changes in which ventricular systole predominated, and were soon 

 followed by acidity of the heart's muscle ; while small doses caused changes in which 

 ventricular diastole predominated, and the reaction of the heart's muscle remained 

 alkaline for some time after standstill of the heart had been produced. 



Further proof of several of these statements is given in the graphic representations 

 that illustrate the two following experiments. 



Experiment CXIII. — Weight of frog (Rana esculenta), 1410 grains. 0*003 grain 



of sulphate of atropine applied to the heart, and afterwards '00 137 5 grain of strophanthin 



in divided doses (Plate XVI.). 



3.0. Frog pithed. 

 On the following day, at 



11.40. Cardiograph applied. 



11.45. Tracing No. 1. 



11.48. Applied to heart - 0015 grain of sulphate of atropine in solution. 



11.53. Tracing No. 2. 



11.54. Second application of 0-0015 grain of sulphate of atropine in solution. 



12.5. Applied to heart 1 minim ( = 0'0005 grain) of - 05 per cent, solution of strophanthin. 



12.6. Curve has fallen closer to abscissa-line. 



1.30. Tracing No. 3. Auricular contractions much increased. Ventricular systole exaggerated. 



2.5. Second application of strophanthin solution, \ minim ( = 000025 grain). Curve has fallen to 

 abscissa-line ; raised the frog and cardiograph slightly. 



2.40. Tracing No. 4. 



3.25. Third application of strophanthin solution, \ minim ( = 0-00025 grain). 



3.27. Cardiograph curve rose further above the abscissa-line. 



3.30. Tracing No. 5. Both auricular and ventricular movements continue to be larger. 



4.7. Fourth application of strophanthin solution, \ minim ( = 0-00025 grain). 



4.24. Tracing No. 6. Irregular. Long oblique line represents slow filling of ventricle before auricular 

 contraction. 



4.46. Tracing No. 7. Do. do. Large auricular and ventricular movements. Pauses in extreme diastole. 



5.12. Tracing No. 8. Do. do. do. do. 



5.54. Fifth application of strophanthin solution, \ minim ( = 0-000125 grain). 



5.58. Tracing No. 9. Pauses in diastole. Large first portion of rapidly ascending line of curve repre- 

 sents filling of ventricle by auricular contraction. 



6.11. Tracing No. 10. Do. Do., but several auricular contractions precede each ventricular contraction. 



6.38. TracingNo.il. Do. Ventricular systole rather more prolonged. 



The cardiograph was now removed : the auricles are large, and the ventricle 

 moderately large and dark. Two or three auricular contractions precede each ventricular 

 contraction, each contraction of the auricles expanding and darkening the ventricle, until 

 it has become of considerable size, when a fairly good ventricular contraction occurs. 

 On the following day, at 



3.30 p.m. General rigor was present, and the heart was motionless, with the ventricle moderately largo 

 and somewhat dark. 



Experiment CXIV. — Weight of frog (Rana esculenta), 1510 grains. 0'003 grain of 

 sulphate of atropine applied to the heart, and afterwards 0*001625 grain of strophanthin 

 in divided doses, during two days (Plate XVII. ). 



11.50. Frog pithed. 



12.6. Cardiograph applied. 



