DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 411 



12.13. Applied to heart 0*0015 grain of sulphate of atropine in solution. 

 12.18. Second application of 0"0015 grain of sulphate of atropine in solution. 

 12.28. Tracing No. 1. 



12.31. Applied to heart J minim ( = 0-00025 grain) of 0-05 per cent, solution of strophanthin. 

 12.42. Second application of strophanthin solution, 1 minim ( = 0-0005 grain). 

 1.0. Ventricular systole seems rather longer than diastole. Curve has risen from abscissa-line. 

 2.2. Tracing No. 2. Curve has fallen. Long pauses are in ventricular diastole. 

 2.22. Tracing No. 3. Long pauses in extreme ventricular diastole. In the curves, the first portion of 

 the nearly perpendicular ascending line represents auricular contraction ; the remainder of the 

 ascending line and the descending line to the end of the horizontal portion of its interruption 

 represents ventricular systole ; and the remainder of the descending line and the oblique line 

 to the abrupt rise represents ventricular diastole. 

 2.45. Third application of strophanthin solution, \ minim ( = 0-000125 grain). 

 4.9. Tracing No. 4. Do. as at 2.2 and 2.22, with pauses in extreme ventricular diastole. 

 5.5. Removed cardiograph. 

 On the following day, at 



3.30. Heart's action rather feeble, but ventricular systole and diastole fairly good. Replaced cardiograph. 



3.43. Tracing No. 5. 



3.44. Fourth application of strophanthin solution, \ minim ( = - 00025 grain). Curve soon fell nearer 



abscissa. Raised frog and cardiograph slightly. 

 4.28. Tracing No. 6. 



4.30. Fifth application of strophanthin solution, \ minim ( = 0-00025 grain). 

 4.57. Sixth application of strophanthin solution, \ minim ( = 0-00025 grain). Curve again fell nearly 



to abscissa-line. Raised frog and cardiograph slightly. 

 5.44. Tracing No. 7. Long pauses in ventricular diastole. 

 6.2. Tracing No. 8. Irregular, long pauses in extreme diastole of ventricle. Three good contractions 



during two rotations of the drum, succeeded by a long pause in extreme diastole of the ventricle. 

 6.7. Removed cardiograph ; the heart is entirely motionless, with the ventricle and auricles large 



and dark. 

 On the third day, at 



2.40. The frog was in general rigor, and the heart, especially the ventricle, was pale and small. 



In these two experiments, strophanthin was applied to the heart in such quantities as 

 to produce changes of the diastolic type, as they, obviously, are the only changes likely to 

 be produced by any influence exerted upon the heart through the vagi nerves. The 

 previous administration of atropine, however, did not succeed in preventing strophanthin 

 from producing changes in which diastole predominated markedly over systole. 



Atropine after Strophanthus. 



In the next series of experiments, an endeavour was made to ascertain if after the 

 production of early or of advanced Strophanthus effects, the administration of atropine 

 prevented the further usual effects from being developed, or removed those effects that 

 had already been developed. 



Experiment CXV. — Large frog. 0'0005 grain of strophanthin applied to heart, and 

 0"004 grain of atropine applied 23 min. afterwards. 



12.15. Cord divided at base of brain. 



12.18. Heart exposed, and pericardium removed. 



12.21 to 12.23. Heart's contractions 22 per 30 sec. 



12.25. Applied to surface of heart 1 minim of solution of 0-05 grain of strophanthin in 100 minims 

 ( = 0-0005 grain). 



