412 DR THOMAS R. FRASER ON STROPHANTHUS HISPIDTJS. 



12.27 to 12.30. Heart's contractions 22 per 30 sec. 



12.35. Heart's contractions 1G per 30 sec. 



12.38 to 12.41. Heart's contractions 13 per 30 sec. Ventricular systole markedly increased. 



12.12. Heart's contractions 10 per 30 sec. Ventricular systole greatly increased and peristaltic; very 



little expansion in diastole. A distinct interval seems to separate contraction of each chamber 



of heart. 



12.48. Applied to heart's surface 0-004 grain of sulphate of atropine in solution. 



12.49. Heart's contractions 5 per 30 sec. Ventricular diastole seems greater; no peristalsis. 



12.51 and 12.52. Heart's contractions 1 per 30 sec, synchronous. Ventricle is larger and darker in diastole. 



12.53. Some general struggles. 



12.53.30. Heart's contractions 10 per 30 sec. Several struggles. 



12.55. Heart's contractions 7 per 30 sec. Then no contraction during 4 min., with ventricle small and 



pale, except a few small areas of darkness. 

 12.59. Heart's contractions spontaneously resumed for 30 sec, when 11 contractions occurred of ventricle 



alone, which, however, remained pale during diastole. 

 12.59.30 to 1.0. Heart motionless in ventricular systole till 

 1.2. When, after some strong general struggles, spontaneous contractions were resumed for 3 min., 



starting at rate of 15 per 30 sec, but gradually becoming slower and feebler; and during this 



time no darkening, and almost no expansion, of the ventricle occurred in the intervals between 



the contractions. 



1.5. Heart motionless. General struggles occurred several times, but were not now followed by resump- 



tion of contractions. Ventricle small and pale. 

 1.7. Mechanical irritation of either auricle produced no contraction; but of the ventricle, a single very 



feeble contraction of the ventricle if the irritation was strong. Latterly, only the left base 



of the ventricle contracted on irritation. 

 1.12 to 1.30. Heart motionless, even on strong irritation, with the ventricle very small and almost 



white, and the auricles rather small. Occasionally throat respirations occur. 



Experiment CXVI. — Weight of frog, 440 grains. 0*0005 grain of strophanthin 

 applied to the heart, and 0'003 grain of atropine applied 15 min. afterwards. 



2.42. Brain destroyed. 



2.45. Heart exposed, and pericardium removed. 



2.48 to 2.51. Heart's contractions 21 per 30 sec 



2-53. Applied to surface of heart 1 minim of solution of - 05 grain of strophanthin in 100 minims 



( = 0-0005 grain). 

 2.55 to 3.3. Heart's contractions 21 per 30 sec. 



3.6. Heart's contractions irregular. "Pouches" form in the ventricle. 



3.7. Heart's contractions 8 per 30 sec, non-synchronous, frequently two contractions of auricles to one of 



ventricle. Ventricular systole strong and prolonged, and diastole brief and incomplete. 



3.8. Applied to surface of heart 0-003 grain of sulphate of atropine in solution. 



3.10 to 3.15. Heart's contractions 10 per 30 sec, generally two contractions of auricle for one contraction 



of ventricle. 

 3.21 to 3.28. Ventricular contractions 6, auricular 17, per 30 sec, and often only the left auricle 



contracts. 



4.0. Heart's contractions have altogether ceased. All the chambers are pale, and the ventricle is very 



small. 



4.1. Mechanical irritation of the ventricle or of either auricle fails to cause any movement. Frequent 



general struggles occur, and the reflexes are active. 



In Experiments CXV. and CXVI., therefore, the application to the heart of atropine 

 after the production of distinct effects by relatively large doses of strophanthin did not 



