414 DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



Experiment CXVIII. — Weight of frog, G20 grains. On first day, '000 5 grain of 

 strophanthin applied to heart, and on each of two subsequent occasions 0*003 grain of 

 atropine ; on second day, 0*003 grain of atropine applied, and 17 min. afterwards 0*00075 

 grain of strophanthin. 



12.44. Destroyed brain. 



12.50. Exposed heart, and removed pericardium. 



12.51 and 12.52. Heart's contractions 20 per 30 sec. 



12.54. Applied to surface of heart 1 minim of solution of - 05 grain of strophanthin in 100 minims 



( = 0-0005 grain). 

 12.56 to 1.14. Heart's contractions from 19 to 13 per 30 sec. Latterly, both systole and diastole more 



complete than before application. 

 1.16 to 1.30. Heart's contractions from 12 to 11 per 30 sec. While ventricular systole continues to be 



very complete and strong, faint pauses occasionally, and especially latterly, occur at the end of 



diastole. 

 1.37 to 1.59. Heart's contractions from 9 to 4 per 30 sec. Distinct pauses in complete diastole of 



ventricle, often for 4 or 5 sec. ; latterly, occasional slight irregularities in rhythm. 

 2.0 to 2.24. Heart's contractions from 4 to 3 per 30 sec, regular and synchronous. Pauses in extreme 



diastole of the ventricle for 7 or 8 sec. 

 2.25. Applied to surface of heart 0-003 grain of sulphate of atropine in solution. 

 2.28 to 3.3. Heart's contractions from 4 to 3 per 30 sec. Ventricle pauses in extreme diastole for 7 or 



8 sec. 

 3.5. Applied to surface of heart 0"003 grain of sulphate of atropine in solution. 

 3.8 to 5.27. Heart's contractions from 3 to 2 per 30 sec. Ventricle pauses in extreme diastole for 8 or 



10 sec. 

 On the following day, at 



3.35 p.m. Heart's contractions 14 per 30 sec. Whole heart is large and very dark in diastole, and a 



faint pause occurs before auricular contraction in extreme ventricular diastole ; ventricular 



systole is weak. 

 3.38. Applied to surface of heart - 003 grain of sulphate of atropine in solution. 

 3.24 to 3.54. Heart's contractions from 14 to 13 per 30 sec. 

 3.55. Applied to surface of heart 1J minims of solution of 0'05 grain strophanthin in 100 minims 



( = 0-00075 grain). 

 3.58 to 4.7. Heart's contractions 12 per 30 sec. Ventricular systole feeble, and when complete the 



ventricle is still dark, and is not very small. 

 4.9. Heart's contractions 12 per 30 sec. Ventricular systole stronger, and longer in duration; diastole 



rather less, and left base of ventricle does not darken during it. 

 4.10 to 4.13. Heart's contractions from 11 to 4 per 30 sec, and only the apex and right base of the 



ventricle now darken during diastole. 

 4.17. Heart's contractions 3 per 30 sec. Ventricular diastole very imperfect; ventricle nearly con- 

 tinuously small and pale. 

 4.21. No diastole or movement of ventricle during 90 sec. ; then a few fairly strong contractions, during 



which, however, the ventricle remains small and pale ; and then complete standstill of heart, 



with ventricle very small and white, and auricles large and distended. 

 4.27 to 4.54. Heart continues motionless in extreme systole of ventricle. The heart was now excised, 



and sections of the wall of the ventricle produced a faint redness of blue litmus-paper. 



In this experiment the inability of atropine to remove extreme diastolic preponder- 

 ance of change was clearly shown during the first day. In the second day, the renewed 

 application of atropine, previously to that of strophanthin, failed in preventing the 

 latter from converting the diastolic into the systolic type of Strophanthus action. 



