DE THOMAS B. FBASEB ON STEOPHANTHUS HISPIDUS. 415 



Experiment CXIX. — Frog weighs 530 grains. 0"00075 grain strophanthin applied 



to the heart, and in 30 min. afterwards 0'003 grain of atropine. 

 1.20. Brain destroyed. 



1.23. Heart exposed, and pericardium removed. 

 1.29 and 1.31. Heart's contractions 14 per 30 sec. 

 1.32. Applied to surface of heart \\ minims of solution of 0-05 grain of strophanthin in 100 minims 



( = 0-00075 grain). 

 1.37. Heart's contractions 13 per 30 sec. 



1.42 to 1.48. Heart's contractions 10 per 30 sec. Slight pause in ventricular diastole. 



1.53. Heart's contractions 9 per 30 sec. Do. Both systole and diastole of ventricle more complete. 



2.0. Heart's contractions 8 per 30 sec. Do. do. 



2.2. Applied to surface of heart - 003 grain of sulphate of atropine in solution. 



2.4 to 2.8. Heart's contractions 8 per 30 sec. Good diastole and increased systole of ventricle. Some 



struggles. 

 2.10 to 2.16. Heart's contractions 9 per 30 sec. A small portion of apex of ventricle does not become 



so dark in diastole as the rest of the ventricle. 

 2.19. Heart's contractions 2 per 30 sec. Pauses for 4 or 5 sec. in extreme diastole of ventricle. 



Both systole and diastole of ventricle very complete. 

 2.24 to 2.28. Pauses of ventricle for from 30 to 50 sec. in extreme diastole, each followed by four 



or five complete systolic contractions. 

 2.32 to 2.40. Do., but ventricle pauses are usually for 60 or 65 sec. 



2.43 to 3.20. Heart motionless for about 2\ min., with ventricle very large and dark; then two good 



contractions in which the ventricle becomes very pale ; and then complete and final standstill, 

 with ventricle very dark and large. 

 6.12. Heart still motionless, but the ventricle is not so dark or large as at 3.20. The auricles are of 



medium size. 

 In the above experiment, after a moderate production of Strophanthus action 

 indicative of the diastolic type, the application of atropine failed to arrest the usual 

 further developments of this type, and even the complete standstill of the heart in 

 extreme ventricular diastole. 



Experiment CXX. — Weight of frog, 558 grains. 0*0005 grain of strophanthin 



applied to the heart, and afterwards (on following day) 0"003 grain of atropine. 

 12.23. Brain destroyed. 



12.30. Exposed heart, and removed pericardium. 

 12.33 to 12.35. Heart's contractions 21 per 30 sec. 

 12.36. Applied to surface of heart 1 minim of solution of 0-05 grain of strophanthin in 100 minims 



( = 0-0005 grain). 

 12.38 to 12.54. Heart's contractions 21 per 30 sec. 

 1.3 to 1.37. Heart's contractions from 19 to 13 per 30 sec. 

 1.39 to 1.51. Heart's contractions from 12 to 9 per 30 sec. Both systole and diastole of ventricle very 



complete, and occasionally a brief pause during latter. Latterly some irregularities in rhythm. 

 1.56 to 2.23. Heart's contractions from 8 to 3 per 30 sec. Regular, with distinct pauses during each 



ventricular diastole. 

 2.27 to 3.25. Heart's contractions 3 per 30 sec. Ventricle sometimes pauses in extreme diastole for 8 sec. 

 3.28. Heart's contractions 2 J per 30 sec, and synchronous. Both ventricular systole and diastole very 

 complete, the former being brief, and the latter slow with long pauses in extreme diastole. 

 Auricular systole immediately precedes the ventricular, and, accordingly, extreme ventricular 

 diastole is attained long before blood is forced into the ventricle by the auricular systole. 

 3.45 to 7.10. Heart's contractions from 1 to 1J per 30 sec. Long pauses in extreme diastole of the ven- 

 tricle, often for 25 sec, in which case the time from the commencement of systole to complete 

 diastole is about 4 sec. 

 VOL. XXXVT. PART II. (NO. 16). 3 R 



