DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



429 



Experiment GXXX V. — continued. 



Time in 



Flow per Min. 



Time in 



Flow per Min. 



Time in 



Flow per Min. 



Minims. 



in Minims. 



Minutes. 



in Minims. 



Minutes. 



in Minims. 



35 



47' 





49 



27 " 





61 



3' 





36 



45 





50 



27 



CO 



62 



3 





37 



44 



CO 



3 



51 



25 



ract c 

 hanth 



63 



4 





38 



44 





52 



23 



64 



2 





39 



41 



OS 



53 



24 



-a §■ 



65 



1 





40 



38 



a, 



54 



24 



tq 2 



66 



2 



d 



41 



36 



o 



55 



23 



to 



67 



1 



►1 



42 



35 



hoa 



Digitalin solution 



68 



2 



.60 



43 



35 



o 



turned on. 



69 



2 



5 



44 



34 



+3 



o 



56 



24' 





70 



1 





45 



32 



63 



49 



57 



22 



■5 



71 



1 





46 



27 





58 



17 



c« 



72 



1 





47 



28 





59 



9 



jSp 



73 



1 





48 



28 





60 



5 



3 







Only moderate oedema occurred, the frog having gained 77 grains on its original 

 weight of 601 grains. 



In Experiment CXXXIV., a solution of 1 : 2000 of extract of Strophanthus reduced 

 the lumen of the blood-vessels so slightly, that in 1 5 min. the flow through them had 

 been lessened by only one-fourth ; whereas a solution of 1 : 20,000 of digitalin, passing 

 through the blood-vessels immediately after the solution of Strophanthus, reduced the 

 flow in 9 min. to one-twentieth, and practically occluded the vessels. 



In Experiment CXXXV., a much stronger solution of Strophanthus extract (1 : 500) 

 than that used in the former experiment, at the end of the long period of 45 min. con- 

 tracted the vessels so that only one-third of the original flow could be maintained ; and 

 still digitalin in a solution forty times weaker (1 : 20,000) was able rapidly to contract 

 the vessels to such an extent that the flow through them had in 5 min. been reduced to 

 nearly one-fifth and in 15 min. to one-twenty-third. 



These results and contrasts are graphically represented in the curves of the experi- 

 ments (Plate XIX.). 



Experiments similar to those that have been described with the extract were also 

 made with strophanthin. 



\ Experiment CXXXVI. 



