DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



435 



The experiment lasted for 2 hours. While normal saline alone was being passed the 

 outflow fell with exceptional rapidity, and this fall was continued for the first 2 or 3 

 min. after 1 : 5000 strophanthin solution had been substituted for the saline. After- 

 wards there was a gradual and moderate fall for 45 min., and then the outflow remained 

 nearly stationary for other 40 min. 



Experiment CXLII. — Normal saline followed by solution of strophanthin in saline, 

 1 : 5000, and 40 min. afterwards by solution of digitalin in saline, 1 : 50,000 (Plate 



XX.). 



Time in 



Flow per Min. in 



Time in 



Flow per Min. in 



Time in 



Flow per Min. in 



Minutes. 



Cub. Cent. 



Minutes. 



Cub. Cent. 



Minutes. 



Cub. Cent. 



1 



2-2" 





24 



2-0' 





49 



1-6 ' 





2 



2-2 





25 



1-9 





50 



1-7 





3 



2-1 





26 



1-9 





51 



1-7 





4 



1-8 





27 



1-9 





52 



1-75 



S3 



5 



1-9 





28 



1-9 





53 



1-75 



3 



6 



1-9 





29 



1-8 





54 



17 



"J 

 p< 

 o 



S-i 



7 



1-9 





30 



1-8 





55 



1-6 



8 



2-0 





31 



1-7 





56 



1-7 



9 



2-1 



d 



32 



1-7 





57 



1-6 



w. 



10 



2-2 



'■M 



33 



1-7 





58 



1-7 





11 



2-1 



C3 

 02 



34 



1-7 



H 



59 



1-6 





12 



20 





35 



1-6 



2 



60 



1-6 





13 



2-1 





36 



1-6 







Digitalin solution 



14 



2-0 





37 



1-6 



rJB 



turned on. 



15 



2-0 





38 



1-7 



o 



61 



1-6 ' 





16 



2-0 





39 



1-8 



m 



62 



1-6 





17 



1-9 





40 



1-8 





63 



1-4 





18 



1-9 





41 



1-7 





64 



1-2 





19 1-9 





42 



1-7 





65 



0-9 







Strophanthin solution 



43 



1-6 





66 



0-8 



\% 



turned on. 



44 



1-7 





67 



0-6 \ 





20 



1"9) . . 



45 



1-7 





68 



0-55 



21 



2-o f -a.s 



46 



1-8 





69 



0-35 





22 



a-ifj| 



47 



1-7 





70 



0-2 





23 



2-1 ) XJl 05 



48 



1-7 





71 



02 





The original weight of the frog was 465 grains, and there was an increase of only 69 

 grains in the experiment. No great contraction of the blood-vessels was produced by con- 

 tact for 40 min. with 1 : 5000 solution of strophanthin. On the substitution of 1 : 50,000 

 solution of digitalin, however, the vessels immediately began to contract, and they had 

 become almost occluded in 10 min. 



In order to complete the comparison between strophanthin and digitalin, for which 

 materials had to some extent been obtained in many of the already described experi- 

 ments, it would be necessary to determine the results of the passing of solutions of 

 digitalin through blood-vessels which had not previously been subjected to the action of 

 Strophanthus. The next three experiments were accordingly performed ; in the first of 

 which a 1 : 100,000 solution, in the second a 1 : 50,000 solution, and in the third a 

 1 : 20,000 solution of digitalin was used. 



