DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



439 



c. Circulation. — Heart and Blood- Vessels — Blood- Pressure Experiments. 



The blood-pressure experiments were made on rabbits, an ordinary Ludwig's kymo- 

 graph being connected with one of the carotid arteries. In the first three experiments, 

 the effects of Strophanthus were produced without any purposely introduced compli- 

 cation ; in the fourth experiment, the vagus was also from time to time stimulated, in 

 order to determine if its cardio-inhibitory function was affected ; and in the fifth experi- 

 ment, atropine was administered before and subsequently to Strophanthus. 



Portions of the blood-pressure curves of four of these experiments, illustrating the 

 most important changes that occurred in the circulation, have been reproduced in Plates 

 XXL, XXII. and XXIII. 



Experiment CXLVI. — Weight of rabbit, 4 lbs. 11 oz. 0*06 grain of strophanthin, 

 dissolved in 30 minims of water, injected under the skin of the abdomen (Plate XXL). 







Blood-pressure 



Pulse 



i-rate 



Respirations 









Substance 





m mm. 





per 



per 



No. of 





Time. 



administered, 

















Trac- 



Notes. 



















and its Dose. 



Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 



ing. 









mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 







4.4.15 





106 



96 



101 



40 



240 



9 



54 



1 



Respiration waves well marked 

 and regular. Pulse move- 

 ments 1 mm. 



4.6 



Strophanthin, 





















to 



0O6 grain, 





















4.8 



injected sub- 

 cutaneously. 





















4.10.20 





118 



108 



113 



37 



222 



7 



42 





Do. Pulse movements occa- 

 sionally l£ mm. 



4.19.8 





102 



96 



99 



36 



216 



9 



54 



2 



Do. do. 



4.32 





















Pulse movements considerably 

 larger, occasionally 3^ mm., 

 but irregular. 



4.32.30 





120 



102 



111 



35 



210 



? 



? 





Respiration waves nearly obli- 

 terated. Some struggles im- 

 mediately preceded, with 

 several irregular oscillations 

 of the pulse curve. 



4.34.44 





72 



64 



68 



27 1 



1 



10 



60 







4.35.35 





72 



48 



60 



15 ? 



90 



12 



72 



3 



Pulse movements large, from 

 2^ to 10 mm., but irregular 

 in size. Respiration waves 

 indistinguishable. 



4.37.38 





54 



36 



45 



16 ? 



? 



12 



72 





Do. 



4.39.35 





68 



50 



59 



15 



90 



12 



72 



4 



Pulse movements large, from 

 6 to 9 mm., and more regular. 

 Respiration waves indistin- 

 guishable. Animal quiet. 



4.41.10 





68 



36 



52 



13 



78 



12 



72 





Pulse movements large, from 

 10 to 12 mm. Do. do. 



4.42.45 





76 



28 



52 



10? 



60? 



6 



36 



5 



Pulse movements from 10 to 14 

 mm. Do. do. Inspiration 

 abrupt. 



4.47 











12 



72 



8 



48 





Do. do. 



4.49 











13 



78 



6 



36 





Do. do. 



4.50.10 





118 



72 



95 



14 



84 



6 



36 





Pulse movements from 6 to 10 

 mm. Do. 



VOL. XXXVI. PART II. (NO. 16). 



3 U 



