440 



DR THOMAS R. FRASER ON STROPHANTHUS HISPIDTJS. 



Experiment CXLVI. — continued. 







Blood-pressure 



Pulse-rate 



Respirations 









Substance 





m mm. 



per 



per 



No. of 





Time. 



administered, 

 and its Dose. 











Trac- 

 ing. 



Notes. 



Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 







mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 







4.50.45 





110 



86 



98 



14 



84 



6 



36 



6 



Pulse movements 9 to 10 mm., 

 nearlv regular and uniform. 

 Do. 



4.53.15 





120 



92 



106 



16 



96 



6 



36 





Do. do. Expiration now 



abrupt. 

 Pulse movements 5 to 6 mm. 



4.55.45 





154 



116 



135 



17 



102 



5 



30 



7 



4.56.20 





162 



146 



154 



25 



150 



3? 







Pulse movements about Z\ 

 mm., and nearly uniform. 

 Animal quiet. Respiration 

 shallow. 



4.57.20 





158 



138 



148 



25 



150 



4 



24 



8 



Do. do. 



4.58 





160 



142 



151 



25 



150 



4 



24 



9 



Pulse movements less regular, 

 from 2 to 3 mm. Do. 



5.0.50 





116 



108 



112 



27 



162 



? 





10 



Do., from 1^ to 2| mm. Do. 



5.2.15 





92 



68 



80 



16 



96 



? 



? 



11 



Pulse movements usually 5 

 mm. 



5.2.40 





74 



56 



63 



17 



102 











5.4.5 





20 



16 



18 



9 



54 



\ 



T 



12 





The fall of blood-pressure which began at 5.0.30 gradually increased until the abscissa was reached at 5.5. At the 

 latter part of this time, a few feeble general spasms occurred. 



After death, at 5.9, the exposed heart was found to be motionless, but irritation produced several weak twitches. 

 The auricles and right ventricle were large, and the left ventricle was small. At 5.12, a cut surface of the left 

 ventricle was acid in reaction. 



In this experiment the blood-pressure, with the exception of an unimportant rise 

 during the injection, was scarcely affected until 4.34, when it began to fall, and it 

 remained at its lowest level (45 to 59 mm.) between 4.37 and 4.43. The pressure then 

 rose gradually until the maximum was reached at about 4.55.20, and this maximum 

 (148 to 154 mm.) was maintained till 5.0. A gradual fall then occurred until the heart 

 ceased to contract at 5.5. 



The pulse movements were largest between 4.40 and 4.43, when the blood-pressure 

 was low ; but even when the pressure was high, the pulse movements were much 

 larger than normal. During the final fall of blood-pressure, the pulse movements 

 became irregular, but large excursions occurred even then and until a short time 

 before death. Large and nearly uniform pulse movements occurred between 4.39.30 

 and 5.1, but they were not so large between 4.56 and 5.1, when the blood-pressure 

 was highest, as between 4.39.30 and 4.55.30, when the blood-pressure was lower than 

 normal. 



The pulse-rate fell markedly at 4.34, and remained slower than normal until death 

 occurred ; but between 4.55 and 5.2, the rate was more rapid than between 4.34 and 

 4.55. 



The respirations increased in frequency soon after the injection, and remained above 



