DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



441 



the normal rate until 4.41. They then gradually became slow, laboured, irregular, and 

 shallow. 



The period of the highest blood-pressure coincided with that of disordered respiration, 

 and of the secondary increase in the pulse-rate. 



Experiment CXLVII. — Weight of rabbit, 4 lbs. 0*012 grain of strophanthin, 

 dissolved in saline, injected in three divided doses into the left jugular vein (Plate 

 XXII. ). 







Blood-pressure 



Pulse-rate 



Respirations 









Substance 





in mm. 





per 



per 



No of 





Time. 



administered, 

















Trac- 



Notes. 



















and its Dose. 



Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 



ing. 









mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 







4.22.20 





110 



104 



107 



45 



270 



8 



48 



1 



Normal. Eespi ration waves well 

 marked. Pulse movements 

 rather less than 1 mm. 



4.25.45 





104 



100 



102 



45 



270 



8* 



51 





Do. do. 



4.26.50 



Strophanthin, 





















to 



0-002 grain, 





















4.27.30 



injected into 

 jugular vein. 





















4.27.35 





114 



108 



111 



44 



264 



H 



57 





Respiration waves well marked. 



4.29.25 





112 



100 



106 



40 



240 



9 



54 





Do. Pulse movements slightly 

 larger than normal, and at 

 irregular, infrequent intervals 

 an intermission occurs, with 

 large diastolic fall (10 mm.) 

 and equally large systolic rise. 



4.32.20 





116 



106 



111 



42 



252 



9 



54 





Do. do. 



4.35.20 





118 



112 



115 



41 



246 



8 



48 





Do. do. 



4.37.4 





116 



108 



112 



39 



234 



9 



54 



2 



Do. do. One of the inter- 

 missions referred to above 

 (4.29.25.) is represented in 

 the tracing. 



4.38.40 



Strophanthin, 



















Almost immediately the pulse 



to 



0-004 grain. 



















movements became larger ; 



4.40 





















at commencement of injection 

 they were 1 mm., and in 10 

 sec. ljr mm. 



4.39.45 





128 



122 



125 



33 



198 



8* 



51 





Respiration waves well marked. 

 Pulse movements still larger, 

 about 2 mm. 



4.40 





128 



118 



123 



32 



192 



8 



48 



3 



Do. do. Second part of trac- 

 ing shows commencement of 

 more frequent intermissions, 

 with exaggerated diastole and 

 systole, which, after lasting 

 for 10 sec, passed gradually 

 into condition shown in next 

 tracing. 



4.40.12 





128 



100 



114 



11 



66 



? 



1 



4 



Respiration waves obliterated, 

 but animal quiet, and breath- 

 ing regularly and fully at rate 

 of 52 per 60 sec. Pulse move- 

 ments very large (9 to 12 

 mm.), and nearly regular. 

 This condition of cardiac 

 action lasted for 25 sec, and 

 then irregularities occurred 

 in rate and size of movement, 

 such as represented in next 

 tracing, No. 5. 



