444 



DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 



At 5.27. The heart was exposed ; occasionally faint twitches of auricles, varied by weak peristaltic movements ; 



rarely feeble twitches of the right ventricle ; no movement in left ventricle. Lungs rather pale. 



Fairly active peristalsis of large and small intestines. 

 „ 5.30. After ligaturing its vessels, the heart was excised. When an incision was made into the left ventricle 



only a little blood escaped ; but when the right ventricle was incised a large quantity of blood escaped 



from it. 

 „ 5.34. A section of the wall of the left ventricle was found to be faintly acid in reaction. The thigh muscles 



were acid in reaction. 



The blood-pressure was but little affected in this experiment, until it rose moderately 

 during respiratory embarrassments towards the end of the experiment, and sank shortly 

 before death, when the pulse-rate had become very slow. 



The pulse-rate sank after each dose of strophanthin, but it recovered a little before 

 the third dose. The pulse movements were much increased in size. At 4.40, soon after 

 the second dose, the excursions were of large size ; and at this time the blood-pressure 

 was slightly above the normal, and the pulse-rate was much slower than it had originally 

 been. The excursions were also very large at 5.12, after the third dose, when the blood 

 pressure was slightly, and the pulse-rate greatly, below the normal. Large pulse excur- 

 sions also occurred at 5.11, when the pressure was higher than the normal, and the pulse- 

 rate much below the normal. 



The respirations were slowed throughout the experiment, and the temporary 

 rises of blood-pressure, which occurred before the heart's action had become extremely 

 disordered, appeared to coincide with special impairment of the respiratory move- 

 ments. 



Experiment CXLVIII. — Weight of rabbit, 3 lbs. 12 oz. O'Ol grain of strophanthin, 

 dissolved in saline, injected in four divided doses, into the left jugular vein (Plate XXL). 







Blood-pressure 



Pulse-rate 



Respirations 









Substance 





in mm. 





per 



per 



No. of 





Time. 



21 fl m 1 Tl 1 stprpd 

















Trac- 

 in c 



Notes. 



(IMlllllllOLClLM. 



and its Dose. 





















Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 



iii a . 









mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 







3.37 



Strophanthin, 



172 



154 



163 



44 



264 



8 



48 



1 



Pulse and respiration regular. 

 Pulse movements about 1 

 mm. 



3.39 



0-002 grain, 





















to 



into jugular 





















3.41 



vein. 





















3.39.5 





166 



150 



158 



38 



228 



7 



42 





Respiration waves indistinct. 



3.39.50 





168 



154 



161 



32 



192 



11 



42 





Pulse movements larger, l£ to 

 2 mm. Respiration waves 

 indistinct. 



3.40.40 





168 



150 



159 



34 



204 



7 



42 



2 



Do. 



3.43.15 





152 



138 



145 



35 



210 



6 



36 





Do. 



3.44.30 





156 



132 



144 



34 



204 



8 



48 





Do. For a short time at 

 4.43.50 the pulse movements 

 were 4 mm. 



3.47.30 





146 



134 



140 



36 



216 



7 



42 





Respiration waves well marked. 

 Pulse movements l£ to 2 

 mm. 



3.54 





158 



148 



151 



35 



210 



8* 



39 





Do. do. 



