446 



DR THOMAS R. FRASER ON STROPHANTHTJS HISPIDUS. 



Experiment CXL VIII. — continued. 



Time. 



Substance 

 administered, 

 and its Dose. 



Blood-pressure 

 in mm. 



Pulse-rate 

 per 



Respirations 

 per 



No. of 

 Trac- 

 ing. 



Notes. 



Maxi- 

 mum. 



Mini- 

 mum. 



Aver- 

 age. 



10 

 sec. 



CO 

 sec. 



10 

 sec. 



60 

 sec. 



4.45.30 



4.46 



4.46.55 



4.47.50 

 4.48.20 

 4.50.40 



5.4 

 5.4.25 

 5.7.35 





202 



236 



224 



220 

 210 

 176 



84 

 94 

 36 



182 



218 



208 



204 

 196 

 170 



64 



72 

 32 



192 



225 



216 



212 

 203 

 173 



74 

 83 

 34 



23 



33 



28 



32 

 30 

 34 



? 



8? 



5? 



138 



198 



168 



192 

 180 

 204 



? 



48? 

 30? 



3? 



? 



3? 



4? 



? 



1 



? 

 ? 

 ? 



1, 



? 



1 



? 

 1 

 ? 



? 

 ? 

 1 



6 



Respiration waves have almost 

 disappeared. Pulse move- 

 ments large and nearly 

 uniform, 8 to 10 mm. 



Do. Pulse movements uni- 

 form, but not so large as at 

 4.45.30. 



Do. Pulse movements 4k to 6 

 mm., and nearly uniform. 



Do. do. 



Do. do. 



Do. Pulse movements much 

 smaller, though larger than 

 normal, about 2 mm. 



Pulse curve rapidly fell, and 

 pulse movements became 

 almost obliterated, and the 

 rate very slow and irregular. 



Respiration waves very irre- 

 gular, about 4 per 60 sec, 

 but distinguishable until 

 5.7. 



Respiration waves indistinguish- 

 able. Pulse movements irre- 

 gular, about 2 mm., and 

 with very gradual diastolic 

 fall. The movements alto- 

 gether ceased at 5.8.30, when 

 the no-pressure line was | 

 suddenly attained. 



After death, at 5.15, the exposed heart was no longer contracting, but feeble peristaltic movements were occurring 

 in both ventricles, and they continued for 20 sec. At 5.16, the heart was motionless, and no contraction followed 

 strong mechanical irritation. When excised, very little blood escaped from the left ventricle, but a considerable 

 quantity from the right ventricle. The lungs were rather pale. Neither urine nor feces were passed during the 

 experiment, but after death a considerable quantity of urine was found in the bladder. 



In this experiment the blood-pressure was almost unaffected until the second injection 

 of strophanthin, when it rose a little, to fall again to the normal before the third injection, 

 after which it again slowly rose until slightly above the normal. A few minutes after 

 the fourth injection, a marked increase of blood-pressure occurred which, as in the 

 previous experiments, suddenly gave way to a rapid fall a short time before death 

 occurred. 



After the first injection of strophanthin, and throughout the remainder of the 

 experiment, the pulse-rate was slower than normal, but when the blood-pressure 

 was highest, the rate, although still below the normal, was not so slow as at other 

 times. 



The pulse movements were increased after each injection, and the largest movements 



