DR THOMAS R. FRASER ON STROPHANTHUS HISPIDTTS. 



447 



occurred during the high blood-pressure following the fourth and last injection. This 

 result is not the same as in the two previous experiments, in which the largest uniform 

 movements took place when the blood-pressure was low, or but little removed from its 

 initial state. 



The respiration rate increased after the second injection, and it remained, generally, 

 above the normal until 2 min. after the fourth injection had been commenced. The 

 respirations then became slow, irregular, and laboured, and while these characters existed 

 the blood-pressure attained its maximum elevation; and, as has been stated, the pulse 

 movements also were then larger than at any other period of the experiment. The 

 largest pulse movements, however, occurred before the blood-pressure had attained its 

 maximum. 



The experiment, therefore, shows that the pulse movements may be nearly 

 uniformly large even when the blood-pressure is much above its original eleva- 

 tion. 



Experiment CLX1X. — Weight of rabbit, 5 lb. 0*012 grain of strophanthin, dis- 

 solved in weak saline, injected in four divided doses into a jugular vein. Vagus nerve 

 stimulated before and after the administration of strophanthin. 



Time. 



Substance 

 administered, 

 and its Dose. 



Blood-pressure 

 in mm. 



Pulse-rate 

 per 



Kespiration 

 per 



Notes. 



Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 







mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 





4.2 

 4.7.10 





144 



138 



141 



49 



294 



8* 



48 



Left vagus cut. 



Respiration waves well marked. 



4.7.30 



















Vagus stimulated : secondary at 30, 

 no effect ; secondary at 25, heart 

 slowed and pressure fell, tem- 

 porarily. 



Respiration waves well marked. 



4.8.30 





146 



136 



141 



49 



294 



9 



54 



4.10.30 



to 

 4.12.30 



4.10.45 

 4.12.20 

 4.14.20 



Strophanthin, 



0-004 grain, 



into jugular 



vein. 



136 



148 

 144 



126 

 140 

 130 



131 

 144 

 137 



47 

 49 



47 



282 

 294 

 282 



n 



9 



8 



45 



54 

 48 



Do. 

 Do. 

 Do. 



4.14.30 



4.17.15 

 4.21.15 





160 

 120 



150 

 112 



155 

 116 



48 

 50 



288 

 300 



8 



48 

 39 



Vagus stimulated : secondary at 25, 

 heart slowed and pressure fell, tem- 

 porarily. 



Respiration waves well marked. 



Do. 



4.21.35 



4.24.30 



to 

 4.26.30 



Strophanthin, 



0-004 grain. 

















V agus stimulated : secondary at 25, 

 heart slowed and pressure fell, tem- 

 porarily. 



4.25 





132 



126 



129 



46 



276 



8 



48 



Respiration waves well marked. 



VOL. XXXVI. PART II. (NO. 16). 



3 X 



