DR THOMAS E. FRASER ON STROPHANTHUS HISPIDUS. 



449 



Experiment GXLIX. — continued. 



Time. 



Substance 

 administered, 

 and its Dose. 



Blood-pressure 

 in mm. 



Pulse-rate 

 per 



Respiration 

 per 



Notes. 



Maxi- 

 mum. 



Mini- 

 mum. 



Aver- 

 age. 



10 

 sec. 



60 

 sec. 



10 

 sec. 



60 

 sec. 



4.47.40 



4.49.30 









... 





... 







Vagus stimulated : secondary at 25, 

 moderate slowing and very slight 

 fall of pressure. 



Pressure has fallen to the abscissa. 

 For about 60 sec. previously the 

 pressure line was only slightly in- 

 terrupted by very faint oscillations. 



This experiment shows that the cardio-inhibitory function of the vagus is not para- 

 lysed by strophanthus. No long-continued uniform and large pulse excursions were 

 produced in the experiment. 



Experiment CL. — Weight of rabbit, 5 lbs. 2 oz. 0*019 grain of strophanthin and 

 0*35 grain of sulphate of atropine, each dissolved in weak saline, injected in divided 

 doses into the jugular veins. Vagus nerve stimulated from time to time (Plate XXIII. ). 







Blood-pressure 



Pulse-rate 



Respirations 









Substances 





m mm. 



per 



per 



No of 





Time. 



administered, 

 and their 











Trac- 

 ing. 



Notes. 



















Doses. 



Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 









mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 







3.45 





















Artery connected with kymo- 

 graph. 

 Normal curve. Respiration 



3.49.10 





136 



120 



128 



44 



264 



5 



30 



1 























waves well marked. Pulse 























movements J to 1 mm. 



3.50 



















2 



Vagus stimulated : secondary 

 at 25 mm., no effect ; at 20 

 mm., marked slowing and 

 fall of pressure. 



3.53 



Atropine 





















to 



Sulphate, 





















3.5330 



- l grain, 

 injected into 

 jugular vein. 





















3.59 





144 



126 



135 



47 



282 



10 



60 





Respiration waves well marked. 

 Pulse movements J to 1 mm. 



3.59.50 





















Vagus stimulated : secondary 

 at 20 mm., no effect. 



4.0 





















Do. : secondary at 12 mm., no 

 effect. 



4.0.30 





















Do. : secondary at 0, no effect. 



4.3 



Strophanthin, 





















to 



0-003 grain, 





















4.4.30 



injected into 

 jugular vein. 





















4.3.5 



... 



106 



98 



102 



42 



252 



13 



98 





Respiration waves well marked. 



