452 



DR THOMAS R. FRASER ON STROPHANTHUS HISPIDUS. 











Experiment GL.- 



—continued. 











Blood-pressure 



Pulse-rate 



Respirations 









Substances 



in mm. 



per 



per 



No. of 

 Trac- 





Time. 



administered, 

 and their 









Notes. 



















Dosee. 



Maxi- 



Mini- 



Aver- 



10 



60 



10 



60 



ing. 





5.24.15 





mum. 



mum. 



age. 



sec. 



sec. 



sec. 



sec. 

























Vagus stimulated : secondary 























at 10 mm., doubtful slowing. 



5.25 





170 



140 



155 



24 ? 



144 



? 



% 



1 



10 

 J 



Respiration waves indistin- 

 guishable. Pulse movements 





















irregular, majority very large. 



5.25.2 





170 



140 



155 



24 ? 



144 



% 



? 



Vagus stimulated : secondary 























at 20 mm., no effect. 



5.25.35 





















Vagus stimulated : secondary 

 at 15 mm. for 5 sec, slight 

 slowing and fall of pressure 

 for 2 sec. at end of stimula- 

 tion. 



5.26.10 





172 



160 



166 



29 



174 



5 



30 





Respiration waves fairly well 

 marked. Pulse movements 

 regular and moderately large, 

 3 to 4 mm. The pulse 

 changed to these characters 

 at 5.25.50, immediately after 

 some struggles. 



5.26.20 





















Vagus stimulated : secondary 

 at 10 mm. Slowing and fall 











































of pressure. 



5.26.45 





168 



156 



162 



29 



174 



4 



24 





Respiration waves fairly well 

 marked. Pulse regular and 

 movements moderately large, 

 3 to 4 mm. 



5.26.55 



















11 



Vagus stimulated : secondary 

 at 15 mm., no effect. 



5.27.15 





















Vagus stimulated : secondary 

 at 10 mm., distinct slowing 

 and fall of pressure. 



5.27.43 





166 



154 



160 



29 



174 



4 



24 



12 



Respiration and pulse as at 

 5.26.45. 



5.30 





















Began to inject more atropine ; 

 suddenly the pulse curve fell 

 rapidly to 10 mm., and the 

 respirations became very in- 





















frequent and laboured. 



The pulse curve remained at about 10 mm. above the abscissa-line for more than half a minute longer, and during 

 this time the pulse movements were irregular and small (1 to 2 mm.), and at the rate of 24 per 10 sec. 



In this experiment, the atropine, which was administered before strophanthin, 

 produced its usual effects in elevating the blood-pressure, and in increasing the rate 

 of the pulse and of respiration. 



After the first dose of strophanthin the blood-pressure fell slightly, but recovered 

 its former state before the second dose of strophanthin, and it fell again after this 

 dose. The third dose was followed by a still further fall ; but the blood-pressure 

 rose above its original elevation after the fourth and fifth doses, and it remained 

 considerably above the normal until, as in the first three experiments, a sudden great 

 fall occurred a few minutes before the heart ceased to contract. 



The acceleration of the pulse-rate caused by the first injection of atropine, was 



