1895.] The Etiology of Small-Pox. 703 
drawings” as well as Beale’s “ bioplasts (loc. cit.) indicate serious 
misinterpretations of the microscopic pictures. 
L. Voigt described, in 1885,” three different forms of cocci 
from small-pox pustules. All of them would liquefy gelatine, 
and one of them was considered the probable carrier of the 
contagion. No definite results were, however, obtained. There 
were two cocci, and a diplococcus. 
Pohl-Pincus also studied the micrococci found in specific 
eruptions, and showed their passage through the epidermis of 
a calf after inoculation.” 
Hlava“, Bowen and Garré have succeeded in isolating a 
streptococcus (Streptococcus pyogenes). They considered the 
united attack by these pyogenic cocci the cause of the disease. 
Koch and Feiler were, however, of the opinion that although 
some of the saprophytic micro-organisms found in vaccine 
lymph are pathogenic, they do not carry the contagion. 
_ Protopopoff* succeeded in finding a streptococcus which 
corresponds, both macro- and microscopically, to the descrip- 
tions of the Streptoccocus pyogenes. Samples from pure cultures 
were injected in rabbits, dogs and cats, but without effect. 
Although this does not imply that this organism cannot affect 
man, it seems improbable that it could have any causal rela- 
tion to variola. 
Crookshank™ and Copeman” found, in vaccine lymph, great 
numbers of common saprophytic and of some pathogenic 
bacteria, but no specific organism. | 
Rille” observed cocci in the vesicles and blood of persons 
suffering from varicella, but did not apply himself to bacterio- 
logical studies of these organisms. 
21 Correspondenzblatt d. allg. aerztl. Vereins von Thüringen, 1887, No. 2, Sep. 
12 pp. 2 plates. Monatshefte f. prakt. Dermatologie, VI, 1887, No. 10. Sep. 
13 pp. 2 pl. Die Protozoen als Krankheitserreger. Jena, 1890. 
22 Deutsche med. Wochenschrift, XI, 895-897, 1885. 
23 Pohl-Pincus, Untersuch. neb. d. Wirkungsweise der Vaccination, 1882. 
4 Sbornik Lékarsky, II, 96-105, 1887. Cblt. f. Bakt. II, 688, 1887. 
25 Zeitschrift für Heilkunde XI, part 2, 1890. Sep. 7 pp. 
*6 Transact. Seventh Internat. Congr. of Hyg. and Dermogr, LI, 326, 1892. 
1 Thidem, 319-326. 
28 Wiener klinische Wochenschrift, No. 38-39, 1889. 
