80 



D. NOEL PATON, B. P. WATSON, AND J. KERR ON 



the different substances injected. The intensity of the reaction is indicated by the signs 

 0, — , + , + + , and + + + indicating the most intense reaction. 



Substance Used and 

 Species of Animal. 



Foetus. 



Mother. 



Fluids. 



Tissues. 



Urine. 



Urine. 



Kidney. 



Blood. 



Sodium Iodide. 



Guinea-pig 



,, ... 

 Rabbit .... 



Dog ... . 





 Am. All. - 







+ 

 + + 



+ + 

 + + 

 + + 



+ 



+ 



+ + 

 + + + 



+ 



... 



+ 

 + 



Am. + All. 



)) — >) — 



Sodium Ferrocyanide. 



Guinea-pig 



Cat ... . 





 





 





+ 

 + 



+ 

 + 





Fluorescin. 



Guinea-pig 



Rabbit .... 



Dog ... 





 



Am. - ? All. - ? 





 



+ 



+ 



+ 

 + 



+ + 



+ 

 + 



+ 

 + 



+ + 



Sodium Salicylate. 



Rabbit .... 

 Rabbit .... 

 Dog ... . 



Am. -"All. - 



+ 



+ 



+ 



+ 



+ + 



... 





Sodium Sulphindigotate. 



Rabbit .... 

 Cat ... . 



1 

 Am. All. 















+ 

 + 







+ 



+ 



These experiments show (l) that, with the one very doubtful exception of sodium 

 sulphindigotate in one sac in the rabbit in Experiment III., in no case did the substance 

 injected into the maternal circulation appear in the fluids without also being present in 

 the foetus ; and (2) that, when the substance appeared in the fluids, its amount in the 

 fcetal tissues or foetal urine was always much greater. The unsatisfactory nature of 

 sodium sulphindigotate for such investigations is well shown by Experiment XII. 



They therefore show that the transference of material from the mother to the fluids 

 takes place through thefxtus. 



D. J. Copper (Der Ubergang bestimmtes Stoffe von der Mutter in das Fruchtwasser 

 und in den Fotus. Utrecht, 1905) gives the results of three quantitative determinations 



