94 



D. NOEL PATON, B. P. WATSON, AND J. KERR ON 



Nature of the Sugar. — The sugar in the amniotic and allantoic fluids of the sheep 

 and cow reduces Fehling's solution, ferments with yeast, and yields crystals with the 

 character of glucosazone. But it is laevo-rotatory and gives Seliwanoff's lsevulose 

 reaction. It is therefore the ketose, lsevulose. In the allantoic fluid of the dog, the 

 sugar was in such small amounts that its nature could not be investigated. 



G-urber and Grunbaum (Munch, med. Wochen., 1904, 377) have already recorded 

 the presence of leevulose in these fluids in the sheep, cow, and goat. 



Source of the Sugar. — The following facts indicate that the sugar is derived from 

 the foetus : — 



1st. We have found the same sugar in the foetal urine of the sheep to the extent of 

 0"5 to 0*7 per cent. 



2nd. It is present in the foetal blood. By extracting large quantities of foetal blood 

 with alcohol, evaporating with charcoal, and taking up in a small quantity of water, we 

 were able to extract a sugar which was lsevo-rotatory and which gave Seliwanoff's reaction 

 distinctly. The fact that it occurs in larger amounts in the urine than in the blood 

 indicates that its presence is not simply due to the swallowing of amniotic fluid by the 

 foetus. In one case the amount of sugar in the blood was as much as 0'42 per cent. 



We have been unable to demonstrate this sugar in the liver. The amount of 

 carbohydrate present in that organ in the foetal lamb seems to be very small. Chipman 



. TABLE M. 



Nitrogen-Sugar Relations. 





Amniotic. 







Allantoic. 





Weight of 



























Foetus, grms. 



Non-Protein S 



ugar 



G 



Non-Protein 



Sugar 



G 





Nitrogen. ( 



G). 



N 



Nitrogen. 



(G). 



N' 



5 



•0536 



15 



2-7 



•044 



•417 



9 



8 



•0256 



078 



3 









10 



•0592 



058 



0-9 



•075 



■29 



3-8 



13 



•037 



058 



15 



•085 



•34 



4 



35 



•0592 



08 



1-3 



•123 



•37 



3 



46 



•0212 



078 



36 



•107 



•413 



3-8 



270 



•132 



263 



2 



• • ■ 







295 



•02 



113 



56 



• • • 



• *• 





328 



•036 



24 



6-6 





• ■ • 





350 



•06 



123 



2-5 



•235 



•268 



11 



390 



•076 



166 



21 



•198 



•71 



35 



512 



•0928 



25 



2-6 



•297 



•44 



1-4 



530 



•0536 



•31 



5-7 









550 



•02 



217 



10-8 









560 



•0872 



•265 



o 



•2168 



•634 



2 ; 8 



720 



■0424 



•51 



12 









740 



•0331 



161 



4-8 



•173 



■247 



1-4 



1670 



1404 



78 



5 



•154 



•33 



2-1 



