THE PHARMACOLOGICAL ACTION OF HARMALINE. 251 



At 12.0 the cardiac impacts were 21, the respirations 18, in ten seconds. During 

 the next fifteen minutes the animal remained usually with the fore part of the body 

 upright, but with the hind-quarters lying on the side, there being frequent clonic 

 movements of the hind legs. When it was disturbed it could run normally, and when 

 laid on its back it turned over immediately. It uttered cries frequently. 



At 12.20 the hind limbs were somewhat rigid, and in the extended position. 

 Respirations seemed to be more panting, but their rate could not be counted owing to 

 the incessant tremors and clonic movements. 



At 12.32 the conjunctival reflex was duller, and the convulsive movements less 

 violent. The animal generally lay on its side, occasionally assuming the upright 

 position for short periods. Two minutes later it lay on its back, and from this time 

 onwards usually remained lying on its back or side. 



At 1.0 the cardiac impacts were 20 in ten seconds. There were frequent clonic 

 movements of the limbs and jaws. The tongue was often quickly protruded and with- 

 drawn. There were sometimes rapid movements of the eyelids and oscillations of the 

 eyeballs. When the animal was placed in the upright position it made no effort to 

 move forward but slowly fell over on to its side. There was apparently a definite 

 diminution in reflex excitability, for even pricking the skin of the leg with a pin 

 induced no reaction. 



At 3.0 the limb movements were much feebler, though still almost constant. The 

 conjunctival reflex was dull. The body was felt to be abnormally cold. The respira- 

 tions were about 20, and the cardiac impacts about 18, in ten seconds, but fchey were 

 difficult to count accurately. At 4.25 the rectal temperature was 26° C. 



At 7.13 the animal was lying on its side gasping. The respirations were 2 or 3 in 

 ten seconds, irregular in rate and accompanied by gaping of the mouth. The cardiac 

 impacts could not be felt. There were feeble pawing movements of the fore limbs. 

 The hind limbs were quite stiff, as if in rigor mortis. The conjunctival reflex was 

 completely gone, but the animal moved its head feebly when the ear was pinched. 

 The rectal temperature was 21° C. 



At 7.25 all respiratory movements ceased. The thorax was then opened, and the 

 heart was exposed at 7.29 and found to be beating slowly and feebly. 



2. Cats.— Experiment 25.— Cat, male, 1730 grammes. At 11.35 the respirations 

 were 6, the cardiac impacts 34, in ten seconds. 



At 11.40, 0*225 gramme of harmaline hydrochloride dissolved in 2 c.c. Ringer's 

 solution at about body temperature, was injected under the skin of the right flank. 

 This was equal to - 13 gramme per kilogramme. 



At 11.43 the cat was timid and uneasy, and appeared to have hallucinations. He 

 moved sometimes in a circle, trembling and with eyes staring. There were slight 

 tremors of the body. 



At 11.48 he stood mewing loudly, with back arched and limbs extended and 

 upright. The mouth was widely opened, and saliva flowed from it. 



