252 DE JAMES A. GTJNN ON 



At 11.55 he had a sudden, violent convulsion which lasted about thirty seconds, 

 and during which lie fell on his side. After this he remained lying on his side, mewing 

 loudly. The respirations were then easily counted, and were 16 in ten seconds, deep 

 and regular. 



Thereafter the animal had convulsions at 12.1, 12.2, 12.3, 12.5, 12.9, 12.13, 12.20, 

 12.25, and 12.30. These convulsions conformed to a fairly definite type. They 

 generally began by gaping of the mouth, followed suddenly by rapid clonic movements, 

 involving especially the hind limbs ; the animal generally fell on its side. Often 

 ushered in by a cry, with occasionally a short tonic phase prior to the clonic movements, 

 and followed by an interval of flaccid ity during which the respirations were panting, 

 these convulsions frequently bore a strong resemblance to attacks of grand mat. It 

 is also seen that there is a tendency to gradual lengthening of the interval between 

 the attacks. The later convulsions also became less violent, and the animal during the 

 intervals more paretic. Up to 12.20 there was no impairment of the conjunctival reflex. 



At 12.25 the respirations were 20 in ten seconds, regular and deep. The con- 

 junctival reflex was duller, and pinching the tail evoked no reaction. The fore limbs 

 were extended at right angles to the body, while the hind-quarters lay on the side. 



At 12.30 the respirations were 14 in ten seconds, and much feebler. The cardiac 

 impacts were 27 in ten seconds. 



At 12.44 no reaction resulted from strongly pinching the limbs or tail; the 

 conjunctival reflex was almost abolished, but the eyes were closed if blown upon. 



At 1.3 the respirations were 15, the cardiac impacts 25, in ten seconds. The cat 

 was lying quite quiet, and there were no tremors or convulsions. 



At 1.10, apart from the movements of respiration, the animal appeared completely 

 paralysed. When held up by the neck it hung quite limp, and when placed on the 

 floor made no attempt to support itself. 



At 1.13 the respirations were 4 in ten seconds, gasping in character; the cardiac 

 impacts were 15 in ten seconds, feeble and irregular. At 1.14 respirations were 

 reduced to an occasional gasp, and no cardiac impacts could be felt. 



At 1.16 the respirations ceased, and the pupils, which had been medium both 

 before injection and throughout the poisoning, dilated widely. The thorax was now 

 opened and the heart exposed ; there were no contractions of either auricle or ventricle. 

 At 1.18, faradic stimulation of the phrenic nerve with the secondary coil at 550 mm. 

 induced contraction of the diaphragm; at 1.22, stimulation of the sciatic nerve with 

 the secondary coil at 370 mm. caused contraction of the gastrocnemius muscle. 



C. Action on the Cerebro-Spinal Nervous System. 



(a) Brain and Spinal Cord. 



I. In Frogs. — The frog is not a suitable animal for manifesting the action of drugs 

 on the cerebrum, and no symptoms were observed which could be ascribed definitely 



