THE PHARMACOLOGICAL ACTION OF HARMALINE. 



263 



selves, as seen in the case of the frog, than to a stimulation of the vasomotor 

 centre. 



In this experiment a total amount of 0'015 grm. per kilo was injected in divided 



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Fig. 10. 



doses — an amount which would immediately have been fatal if administered 

 by a single injection. About forty minutes after the last injection, however, the 

 blood pressure was still at the level normal to the animal, though the pulse rate had 



Fig. 11. 



diminished so greatly as from 42 to 18 per ten seconds. It would appear, therefore, 

 that in the rabbit very large doses of harmaline may bring about a constriction of 

 the arterioles so physiologically balanced that it may exactly maintain the level of 

 blood pressure in spite of a profound fall of the pulse rate, 



