THE PHARMACOLOGICAL ACTION OF TUTU. 



293 



The course of the intoxication in rabbits after different doses of tutin is shown in 

 the following protocols. Experiment I. gives the effect of a nearly lethal dose, and 



Experiment II. — O'OOl grm. Tutin per kg. Rabbit. Weight, 950 grm. 



Time. 



Heart- 



Respira- 



Tempera- 



Observations. 





beats. 



tion. 



ture. 





12.0 



276 



72 



39-1° 



Temperature of room 16° C. 



12.5 







... 



0"48 c.c. 1 in 500 tutin solution injected under skin of back. 



12.16 



192 



132 





Slight dyspnoea. Ear vessels somewhat dilated. Animal has been 

 resting since injection. 



12.23 



180 



144 







12.28 



192 



168 





Lay down and stretched hind legs back. 



12.35 



174 



156 



37 -6* 



When lifted up the hind feet clung to the fingers. 



12.54 



198 



132 





Slight trembling occurred at intervals, and terminated in a 

 convulsion two minutes later, which was mainly tonic, and 

 seemed to prove almost fatal. 



12.58 









Tremors of mouth, and later of fore limbs, recommenced and 

 gradually increased in intensity. The convulsion lasted two 

 minutes. Afterwards the animal lay on venter with hind legs 

 stretched backwards as before. 



1.7 



240 



84 



371° 



Fine tremors present apparently over whole body. 



1.20 



236 



144 





Tremors more marked ; otherwise same. 



1.35 



216 



108 



37-6° 





2.8 



276 



108 



38-r 



Somewhat better. 



3.8 



276 



108 



387° 



Much better ; has not moved since last note. 



4.5 



258 



84 



39-2° 



Apparently well. 



Experiment II. the effect of a minimal convulsant dose. Experiment III. shows the 

 result of administering a non-convulsive dose. P refers to the number of heart-beats, 

 and R to the number of respirations per minute ; T refers to rectal temperature. 



Experiment III. — 0-0005 grm. Tutin per kg. Rabbit. Weight, 1100 grm. 



Time. 



Heart- 

 beats. 



Respira- 

 tion. 



Tempera 

 ture. 



Observations. 



12.0 



252 



66 



395° 



Temperature of room 16° C. 



12.4 









- 28 c.c. 1 in 500 tutin solution inje-ted under skin of back. 



12.10 



252 







Animal moving about. 



12.15 



216 



156 





Appears slightly depressed. Ear vessels dilated somewhat. 



12.21 



192 



180 





Dyspnoea Heart-beats feel more forcible. 



12.28 



186 



228 





Seems distinctly depressed, and shows no inclination to move. 



12.33 



156 



228 



37-6° 



When animal was lifted up the movements of the hind legs were 

 found to be weaker and inco-ordinate. 



12.44 



168 



144 



. . . 



Trembling slightly. Ear vessels more contracted. 



12.53 



156 



156 







1.3 



168 



108 



38-0° 





1.18 



204 



144 







1.33 



228 



96 



387° 



Trembling still present. 



2.0 



264 



84 



39-6° 



Apparently well. 



3.3 



252 



72 







