THE PHARMACOLOGICAL ACTION OF TUTU. 



297 



Experiment VI. 



-Rabbit. Chloroform. Blood Pressure from Right Carotid Artery. 

 Respiration recorded by Head's Method. 



Time. 



Blood Pressure 

 in mm. 



Pulse Rate 

 per 10". 



Respirations 

 per 10". 





Remarks. 





3.34 



61 



27 



14-3 









3.35 









000025 grm. 



tutin injected into left ext. 



jugular vein. 



3.40 



61 



245 



13 7 









3.45 



61 



24 



13-8 









3.50 



62 



23 



13 









3.53 



65 



22-5 



11-5 









3.55 



66 



23 



8 









3.57 



65 



23-2 



10-8 









4.5 



66 



22 



16 









4.7 









000025 grm. 



tutin injected. 





4.12 



65 



22 



13-5 









4.17 



65 



21 



13 









4.22 



65 



21 



12-3 









4.25 



63 



21 



123 









4.27 



57 



20 



107 









4.30 



52 



20 



13 









Subsequently, a small dose of coriamyrtin (0"0001 grm.), and afterwards two doses of tutin (0-0005 grm. 

 and - 001 grm.), were injected. In each case the blood pressure and pulse rate fell slightly, and the fre- 

 quency of respiration very distinctly. 



Heart 



250 



200 



150 













































































































< 



1 





















































\ 





















































\ 





















































\ 





















































\ 



v 





















1 



► 































\ 



















,' 





\ 

 \ 































\ 















-- 



' 





































\ 











/ 



p 















\ 





































• 



















\ 































• 



' 





















^ 



» - 







-H 



► 





















1 







































































































\l 





















































' \ 



















































/ 





















































/ 





\ 























/ 



:>-_ 























/ 



) 





\ 























/ 









^< 



> 















/ 







o 



\ 



















/ 



























/ 









\ 



\ 















/ 



























/ 













\ 



\ 













/ 



























/ 

























/ 



























< 



1 























c 



> 









































































































































































































































Resp. 



150 



100 



50 



Minutes 10 20 30 40 50 



Fig. 2. — Similar diagram showing effect of 1 mg. tutin per kg. body-weight up to occurrence of convulsion. Rabbit, 950 grm. 



