THE PHARMACOLOGICAL ACTION OF TUTU. 



303 



character seen at the commencement of the tracing twenty-two minutes after stopping 

 the ether inhalation. Subsequently the effect of a very small concentration of ether 

 vapour was tried. The anaesthetising tube was merely placed on one of the mouths 

 of the Woulff's bottle, and a second limb of the tracheal cannula was left open. The 

 effect, although less marked than in the preceding case, was strikingly sudden. Only 

 one tonic-clonic convulsion occurred after the commencement of the inhalation. Within 



4.42 



Fig. 6. — Effect of inhalation of ether on tutin convulsions in decerebrate rabbit. Same animal as preceding 

 figures. Anaesthetising concentration of ether vapour given at point marked by arrow. R = right, L — left 

 fore limb. Time in seconds, x § linear. 



twenty-three seconds true convulsive movements had ceased and become replaced by 

 single contractions, occurring at first in small groups, and later alone. These con- 

 tractions ceased eighty seconds after the commencement of the inhalation, which 

 was continued for two and a quarter minutes. JRegular small contractions commenced 

 ninety seconds later, and the typical tonic-clonic convulsions quickly developed 

 and became distinct in one minute. A second similar inhalation of ether produced 

 practically the same result. 



It is evident, therefore, that the convulsions occurring in decerebrate animals are 

 TRANS. ROY. SOC. EDIN, VOL. XL VII. PART II. (NO. 13). 46 



