350 



SIR THOMAS R. FRASER AND MR ALISTER T. MACKENZIE ON 



Table VI. — Minimum-Lethal Dose of Extract for Rats. 



No. of 

 Experiment. 



Weight of 

 Animal in grams. 



Actual Dose 

 in grams. 



Dose per kilo- 

 gram of Animal 

 in grams. 



Result. 



18 



240 



0-0072 



003 



Recovery. Very slight effects. 



19 



205 



0-041 



0-2 



Recovery. Slight effects. 



20 



185 



00555 



0-3 



Death in 4 days. 



21 



205 



0-123 



0-6 



Death in 4 days. 



22 



130 



0-0975 



0-75 



Death in 3 days. 



23 



180 



0-27 



1-5 



Death in 5 hours. 



Table VII. — Minimum-Lethal Dose of Extract for Rabbits. 



No. of 

 Ex penmen t. 



Weight of 

 Animal in grams. 



Actual Dose 

 in grams. 



Dose per kilo- 

 gram of Animal 

 in grams. 



Result. 



24 



2000 



0-001 



0-0005 



Recovery. Very slight effects. 



25 



2000 



0-0015 



0-00075 



Recovery. Very slight effects. 



26 



2210 



0-00177 



0-0008 



Recovery. Very slight effects. 



27 



1940 



0001745 



00009 



Recovery. Very slight effects. 



28 



1870 



0-00187 



0-001 



Recovery. Distinct effects. 



29 



2500 



0-00275 



o-oon 



Recovery. Distinct effects. 



30 



1970 



0002364 



0-0012 



Recovery. Distinct effects. 



31 



1750 



0-002275 



0-0013 



Recovery. Distinct effects. 



32 



1640 



0-002296 



0-0014 



Recovery. Severe effects. 



33 



2330 



0-003262 



0-0014 



Recovery. Severe effects. 



34 



1460 



000219 



0-0015 



Death in 1 hour 25 minutes. 



35 



2200 



00033 



00015 



Death in 2 hours 2 minutes. 



36 



2150 



0-0043 



0002 



Death in 1 hour 17 minutes. 



Table VIII. — Minimum-Lethal Dose of Extract for Cats. 



No. of 

 Experiment. 



Weight of 

 Animal in grams. 



Actual Dose 

 in grams. 



Dose per kilo- 

 gram of Animal 

 in grams. 



Result. 



38 

 39 



2950 

 2230 



0-00295 

 0-00446 



o-ooi 



0-002 



Distinct effects. Recovery. 

 Death in 1 hour 15 minutes. 



The following table (IX.) gives the results following the injection of the same extract 

 into the marginal vein of the left ear in rabbits. 



