STROPHANTHUS SARMENTOSUS : ITS PHARMACOLOGICAL ACTION. 357 



impacts 32 per 10 seconds. In 1 hour after the injection, the respirations were 24 

 per 10 seconds and irregular in time ; the cardiac impacts were 35 per 10 seconds, less 

 distinct and slightly irregular in time ; the rectal temperature was 37 '5° C; and fine 

 tremors were occurring in the muscles of the neck. In 1 hour 25 minutes after the 

 injection, severe dyspnoea occurred, lasting for three minutes, during which the rabbit's 

 head was projected forwards, the mouth partly open, the nostrils dilated, and sucking 

 noises were made, the thorax appearing to be fixed ; and the cardiac impacts were rapid 

 and indistinct. In 1 hour 45 minutes, the respirations were 21 per 10 seconds and 

 regular; the cardiac impacts were 40 per 10 seconds, slightly irregular and much more 

 distinct ; the pupil was unchanged, the conjunctival reflex was acute ; and the rabbit sat 

 in a normal attitude and ate food. In 2 hours after the injection, the respirations were 

 21 per 10 seconds and somewhat irregular in time ; the cardiac impacts were 36 per 

 10 seconds and markedly irregular in time and force ; the rectal temperature was 38° C. 

 In 2 hours 30 minutes, the respirations were 22 per 1 seconds and irregular in time ; 

 the cardiac impacts were 45 per 10 seconds, strong and slightly irregular in time ; and 

 the left pupil measured 6 mm. transversely, the conjunctival reflex was acute, and there 

 was no sign of discomfort. In 3 hours after the injection, the respirations were 29 

 per 10 seconds and slightly irregular in time; the cardiac impacts were 42 per 10 

 seconds, regular and tapping in character ; the conjunctival reflex was acute ; the rectal 

 temperature 37 '5° C. ; faeces had been passed ; and the rabbit was alert, but not rest- 

 less. In 3 hours 10 minutes after the injection, the respirations were 21 per 10 seconds, 

 and regular; the cardiac impacts were 50 per 10 seconds, feeble but regular; the left 

 pupil measured 5 mm. transversely ; and the rabbit was restless, and sat very erect, with 

 the head nodding with the respiratory movements. Three hours 30 minutes after the 

 injection, the respirations were 18 per 10 seconds and the cardiac impacts were 42 per 10 

 seconds, regular and abrupt, and the animal ate food. Four hours 30 minutes after the 

 injection, the respirations were 21 per 10 seconds, the cardiac impacts were 39 per 10 

 seconds, regular and easily felt, and the rabbit sat upright with ears erect. Four hours 53 

 minutes after the injection, there were tremors of the neck muscles. Five hours after the 

 injection, the respirations were 17 per 10 seconds and irregular in time, the cardiac 

 impacts were 40 per 10 seconds and irregular in force ; the left pupil measured 4 mm. 

 transversely and the conjunctival reflex was acute ; the rectal temperature was 3 7 '5° C. ; 

 and the rabbit sat upright with ears erect and back well arched. Five hours 40 minutes 

 after the injection, the respirations were 12 per 10 seconds and regular; the cardiac 

 impacts were 38 per 10 seconds and thumping in character ; the transverse measurement 

 of the left pupil was 4 mm., the conjunctival reflex was acute ; tremors were present 

 in the neck muscles and in those of the cheeks ; and occasionally a faint sucking noise 

 was made and chewing movements of the lower jaw occurred. Seven hours 30 minutes 

 after the injection, the respirations were 14 per 10 seconds and irregular; the cardiac 

 impacts were 40 per 10 seconds, regular and easily felt ; the rectal temperature was 



38 "5° C. ; and the rabbit was alert. Twenty-four hours 30 minutes after the injection, 

 TRANS. ROY. SOC. EDIN., VOL, XLVII. PART II. (NO. 15). 54 



