STROPHANTHUS SARMENTOSUS : ITS PHARMACOLOGICAL ACTION. 365 



just above the urostyle, with the secondary coil at 100 mm., caused the frog to jump. 

 Twenty minutes after the injection, the attitude of the frog was still normal ; the right 

 (protected) foot was withdrawn when its web was stimulated with the secondary coil 

 at 60 mm., and the left (unprotected) foot was withdrawn when its web was stimulated 

 at 100 mm. ; and the frog jumped away when the skin over the cord, just above 

 the proximal end of the urostyle, was stimulated with the coil at 80 mm. Twenty-five 

 minutes after the injection, the heart was exposed and was seen to be completely 

 motionless, with the ventricle in systole. Thirty minutes after the injection, the frog 

 was lying flaccidly' on the thorax and abdomen ; stimulation of the right (protected) 

 web with the secondary coil at 60 mm., and stimulation of the unprotected left web 

 at 120 mm., caused crossed reflexes; and both posterior extremities were rapidly and 

 fully extended when the skin over the spinal cord just above the proximal end of the 

 urostyle was stimulated with the secondary coil at 80 mm. Thirty -five minutes after 

 the injection, direct stimulation of the right (protected) sciatic with the secondary coil 

 at 370 mm. caused a contraction of the right gastrocnemius, and stimulation of the 

 left (unprotected) sciatic at 370 mm. caused a similar contraction of the left gastro- 

 cnemius. Forty-five minutes after the injection, stimulation of the skin just above 

 the proximal end of the urostyle and over the spinal cord with the secondary coil at 

 110 mm. caused rapid extension of both posterior extremities, the left (unprotected) 

 being more forcibly extended than the right. Fifty minutes after the injection, similar 

 contractions of their respective gastrocnemii were obtained by direct stimulation of the 

 right (protected) sciatic with the secondary coil at 430 mm., and of the left (unpro- 

 tected) sciatic at 410 mm., and a crossed reflex was obtained on stimulating the right 

 sciatic at 350 mm. and the left sciatic at 300 mm. Fifty-five minutes after the 

 injection, no reflex could be obtained by the stimulation of either foot with the 

 secondary coil at zero, while stimulation over the lower part of the spinal cord at 

 70 mm. caused rapid extension of both limbs, and at 80 mm. caused slight extension 

 of the left (unprotected) limb only. Two hours after injection galvanic stimulation of 

 either foot with the secondary coil at zero produced no reflex ; on stimulation over the 

 spinal cord just above the urostyle with the secondary coil at 80 mm., both gastro- 

 cnemii moved slightly ; and at zero mm., a more distinct contraction of the gastrocnemii 

 occurred, but no movement of the limbs resulted in either instance. Two hours 5 minutes 

 after the injection, similar contractions of the gastrocnemii were elicited by stimulating 

 the right sciatic nerve at 330 mm. and the left sciatic nerve at 370 mm., but no reflex 

 movements were produced on stimulating either sciatic directly with the secondary 

 coil at zero. Two hours 50 minutes after the injection, no movements of any kind 

 resulted from galvanic stimulation of either foot at zero, or of the skin over the spinal 

 cord at zero. Three hours after injection, equal movements of their respective 

 gastrocnemii were produced by galvanic stimulation of the right sciatic nerve with the 

 secondary coil at 120 mm. and of the left sciatic nerve at 140 mm., 'and at this time 

 sections of the right (protected) thigh muscles were feebly acid to litmus paper, whereas 

 TRANS. ROY. SOC. EDIN., VOL. XLVII. PART II. (NO. 15). 55 



