STROPHANTHUS SAKMENTOSUS : ITS PHARMACOLOGICAL ACTION. 



379 



the chambers uniformly ; the ventricle was of a pale pink colour in systole and never 

 white ; and ventricular systole continued to occupy two-thirds of the ventricular cycle. 

 The number of contractions, however, had fallen from eight to six per 10 seconds, and 

 the ventricle did not become quite so small in systole as at the beginning of the 

 experiment. After 48 hours, general reflexes could still be elicited. 



Experiment LIU. — 00001 25 gram of extract placed within the pericardial sac 

 of a frog {Rana temporaria). 



Interval. 



Before Strophanthus. 

 12 minutes . 



After Strophanthus. 

 10 minutes . 



20 



30 



!» 



40 



)* 



60 

 123 





170 „ 



190 

 215 



260 „ 



275 „ 

 278 „ 



Contractions 



in 10 seconds. 



Auricles. 



Ventricle. 



7 



7 



7 



7 



6 



6 



6 



6 



6 



6 



6 



6 



4 



4 



4 



4 



4 



4 



4 



4 



3 



3 



Notes. 



Contractions regular and powerful; ventricular systole 

 occupies two- thirds of the cardiac cycle ; in diastole, the 

 ventricle is uniformly dark red in colour, and in systole it 

 is pink and moderately small ; auricular systole and ven- 

 tricular diastole are synchronous. 



0-0000125 gram of extract in Singer's solution was inserted 

 inside the pericardium. 



Notes as before, but the ventricle possibly becomes paler in 



systole. 

 Contractions are regular and powerful ; ventricular systole 



continues to occupy two-thirds of the cycle; in diastole, 



the ventricle appears to be darker than before the applica- 

 tion of the extract ; in systole, it is distinctly smaller and 



paler. 

 Contractions regular and powerful ; ventricular systole and 



diastole each occupy half of the cycle; the ventricle begins 



to dilate before auricular systole occurs. 

 Contractions regular and powerful ; ventricular systole again 



occupies two-thirds of the cycle ; auricular systole and 



ventricular diastole are again synchronous. 

 As last noted. 

 Contractions regular and powerful ; ventricular systole and 



diastole each occupy half of the cycle ; ventricular diastole 



is performed well and uniformly ; the ventricle contracts 



uniformly and becomes pale pink. 

 Ventricular diastole occupies two-thirds of the ventricular 



cycle ; systole is powerful ; ventricular diastole is in two 



phases, the first is a slight relaxation of the ventricle 



immediately after its own systole ; the second corresponds 



with the systole of the auricles. 

 As last noted. 

 Eegular and powerful contractions ; ventricular systole and 



diastole each occupy half the cycle ; the ventricle is now 



less pale in systole. 

 Ventricular diastole now occupies two-thirds of the cycle ; 



at irregular intervals the heart is arrested in full diastole 



for periods of about 15 seconds. 

 The heart was arrested in diastole for 15 seconds and the 



frog struggled violently ; the ventricle became greatly 



dilated and then began to contract regularly. 

 The heart is contracting regularly and powerfully. 



