396 



SIR THOMAS R. FRASER AND MR ALISTER T. MACKENZIE ON 



Experiment LXVI. (Rana temporaries). — Ringer's solution; then extract of 

 S. sarmentosus in Ringer's solution (1 in 25,000); then digitalin* in Ringer's solution 

 (1 in 20,000). (Plate IX.) 



Time in Minutes. 



Flow per Minute 

 in c. c. 



Time in Minutes. 



Flow per Minute 

 in c.c. 



Time in Minutes. 



Flow per Minute 

 in c.c. 



1 



1-2 



31 



1-3 



63 



1-2 



2 



1-4 



32 



1 



4 



64 



11 



3 



1-4 



33 



1 



4 



65 



11 



4 



1-4 



34 



1 



4 



66 



1-1 



5 



1-6 



35 



1 



4 



67 



1-1 



6 



1-5 



36 



1 



3 



68 



11 



7 



1-4 



37 



1 



4 



69 



11 



8 



1-4 



38 



1 



4 



70 



11 



9 



1-4 



39 



1 



3 



71 



1-2 



10 



1-7 



40 



1 



4 



72 



1-1 



11 



1-8 



41 



1 



4 



73 



1-1 



12 



1-5 



42 



1 



4 



74 



1-0 



13 



14 



1-4 

 1-4 



43 



44 



1 



1 



3 

 3 



Digitalin 



perfused. 



Strophanthus perfused. 



45 

 46 



1 



1 



3 

 4 



75 

 76 



1-1 

 1-0 



15 



1-4 



47 



1 



4 



77 



11 



16 



1-5 



48 



1 



3 



78 



11 



17 



1-4 



49 



1 



2 



79 



0-6 



18 



1-5 



50 



1 



3 



80 



03 



19 



1-4 



51 



1 



2 



81 



03 



20 



1-5 



52 



1 



2 



82 



03 



21 



1-5 



53 



1 



3 



83 



0-3 



22 



14 



54 



1 



3 



84 



0-2 



23 



1-5 



55 



1 



3 



85 



0-2 



24 



1-4 



56 



1 



3 



86 



o-i 



25 



1-4 



57 



1 



2 



87 



o-i 



26 



14 



58 



1 



2 



88 



o-i 



27 



1-4 



59 



1 



2 



89 



01 



28 



1-5 



60 



1 



1 



90 



0-05 



29 



1-7 



61 



1 



2 







30 



1-5 



62 



1-2 







The frog weighed 20 grams before and 24 grams after the experiment — a gain of 

 4 grams. 



The blood-vessels were practically unaffected by this solution of S. sarmentosus 

 extract in 60 minutes, and then digitalin produced nearly complete occlusion in 15 

 minutes. 



* In this and the following experiment, Merck's " Digitalin pur. pulv. " was used. Its minimum-lethal dose for 

 frogs was found to be - 045 gram per kilo., or thirteen times larger than that of the extract of S. sarmentosus (0'00.'J5 

 gram per kilo.) used in our experiments. 



[Experiment LXVII. 



