STROPHANTHUS SARMENTOSUS : ITS PHARMACOLOGICAL ACTION. 



399 



blood-vessels. It may be pointed out that the presence in the blood of a man 

 weighing 11 stones of a solution of 1 : 10,000 would imply the subcutaneous 

 administration of at least 0"54 gram of the extract, or more than twice the probable 

 minimum-lethal dose, and, therefore, a dose that has no therapeutic interest. 



(c) Blood-Pressure Experiments. 



Blood-pressure experiments were performed on rabbits, the record being made by a 

 Ludwig's kymograph connected with the right carotid artery. The time marked on each 

 figure corresponds to the first movement of the time-signal recorded on that tracing. 



In the first two experiments, no other factor than the administration of Strophan- 

 thus was introduced. In the third experiment, the vagus was stimulated from time to 

 time. In the fourth experiment, atropine was administered along with Strophanthus. 



Experiment LXIX. — Weight of rabbit, 1900 grams. 0"00171 gram of extract in 

 - S55 c.c. of Ringer's solution injected into the left jugular vein ( = 0'0009 gram per 

 kilogram). (Plate X.) 



Time. 



12.17.10 

 12.17.50 

 12.18.0 



to 

 12.18.10 



12.19.20 



12.21.0 

 12.23.50 



12.26.40 



12.28.40 

 12.36 



12.55 

 1.10.30 



1.55.10 

 2.40 

 3.18 



3.18.50 

 to 



3.18.55 



3.19.55 



3.20.50 

 3.21.20 



Substance 

 administered, 

 and its Dose. 



Extract of 

 Strophanthus, 



0'0009 gram per 

 kilogram, injected 

 into jugular vein. 



Blood-pressure 

 in ram. of Hg. 



Extract of 

 Strophanthus, 



0-0009 gram per 

 kilogram, injected 



Maxi- 

 mum. 



84 

 86 



112 



104 

 90 



84 



96 

 76 



72 

 58 



54 



72 

 70 



78 



70 

 58 



Mini- Aver- 

 mum. age. 



78 

 78 



104 



100 



'84 



72 



70 

 76 



72 

 58 



54 



72 

 70 



64 



58 

 46 



81 



82 



108 



102 



87 



78 



83 

 76 



72 

 58 



54 

 72 

 70 



71 



64 



52 



Pulse 

 rate per 

 10 sec. 



36 

 35 



34 



35 

 39 



48 



52 

 37 



43 

 42 



38 

 36 

 34 



32 



29 



1 



Respira- 

 tions per 

 10 sec. 



14 

 13 



12 



12 

 14 



16 



18 

 15 



15 

 15 



12 

 12 

 10 



10 



13 

 13 



No. of 

 Trac- 

 ing. 



10 



11 



12 

 13 



Notes. 



Pulse movements 1 mm. 

 Do. 



Pulse movements 1 mm. and T5 mm. 

 alternately. 



Do. Respiratory movements increased. 



Pulse movements 1 mm. and less, some- 

 what irregular. 



Pulse movements very small. Respira- 

 tory movements continue to be large. 

 Blood -pressure varies rapidly. 



Do. 



Pulse movements 05 mm. Respiratory 

 movements continue large. Level of 

 blood-pressure is constant. 



Do. 



Pulse movements very small. Respira- 

 tory movements continue to be large. 

 Height of blood-pressure constant. 



Do. 



Do. 



Do. 



Pulse movements small. Respiratory 

 movements large. Height of blood- 

 pressure varies rapidly. 



Do. 



Rapid fall in blood-pressure. 



