STROPHANTHUS SARMENTOSUS : ITS PHARMACOLOGICAL ACTION. 



401 



Experiment LXX. — Weight of rabbit, 1520 grams. 0*001216 gram of extract 

 injected into the left jugular vein in four equal parts. Each injection = 0*0002 gram 

 per kilogram, and the total dose = 0*0008 gram per kilogram. (Plate XI.) 



Time. 



3.24.10 

 3.25.20 



to 

 3.25.30 



3.26.0 

 3.26.30 

 3.28.20 

 3.29.10 



3.31.0 

 3.32.10 

 3.35.10 

 335.40 



to 

 3.35.50 



3.36.10 

 3.37.0 



3.38.10 

 3.40.0 



3.41.10 

 to 



3.4120 



3.41.40 

 3.42.0 



3.44.10 

 3.46.0 



3.47.40 



3.50.0 

 3.50.40 



to 

 350.50 



3.51.20 

 3.52.10 



3.53.0 

 3.54.0 



3.55.30 



3.56.20 

 3.57.10 



Substance 

 administered, 

 and its Dose. 



Extract of 

 Strophanthus, 



0-0002 gram per 

 kilogram, injected 

 into jugular vein 



Extract of 

 Strophanthus, 



0-0002 gram per 

 kilogram, injected. 



Extract of 

 Strophanthus, 



0-0002 gram per 

 kilogram, injected 



Blood-pressure 

 in mm. of Hg. 



Extract of 

 Strophanthus, 



0-0002 gram per 

 kilogram, injected 



Maxi- 



Mini- 



mum. 



mum. 

 90 



92 



94 



88 



98 



94 



100 



98 



98 



96 



96 



94 



94 



92 



94 



88 



94 



90 



100 



98 



100 



98 



98 



96 



100 



92 



102 



100 



100 



98 



96 



94 



100 



94 



98 



92 



98 



92 



106 



94 



110 



98 



116 



96 



90 



70 



98 



68 



90 





Aver- 

 age. 



Pulse- 

 rate per 

 10 sec. 



91 



91 

 96 

 99 

 97 

 95 

 93 

 91 



92 

 99 

 99 

 97 



96 

 101 

 99 

 95 

 97 



95 



95 

 100 



104 

 106 



80 

 83 



35 



36 

 34 

 34 

 33 

 34 

 34 

 34 



34 

 34 

 34 

 35 



33 

 32 

 33 



31 

 28 



26 



27 

 25 



23 

 21 



11 



13 

 13 



Respira- 



No. of 



tions per 



Trac- 



10 sec. 



ing. 



22 



1 



24 





23 



2 



23 





23 





22 





23 



3 



24 



4 



22 





22 



5 



22 





23 



6 



24 





23 



7 



23 





23 





24 



8 



22 





22 





23 



9 



24 





23 



10 



6 







11 





12 



Notes. 



Pulse movements less than 1 mm. 



Do. 



Do. 



Do. Respiratory movements diminished. 

 A few pulse movements are 1 mm. 



Many pulse movements are 1 mm. 



Do. 



Do. 



Do. 



Do. Respiratory movements smaller. 

 Many pulse movements are 2 mm. The 



respiratory movements are much 



diminished. 



Some pulse movements are 2mm. ; oscilla- 

 tions in the blood -pressure are well 

 marked. The respiratory movements 

 are feeble. 



Do. 



Some pulse movements are 3 mm. 

 These alternate with small movements. 

 Respiratory movements are feeble, 

 and the blood-pressure oscillates 

 rapidly. 



Pulse movements of 4 mm. alternate with 

 pulse movements of 2 mm. Respira- 

 tory movements very large. 



Large pulse movements occur. The 

 respirations are very deep and sighing. 



The pulse movements are moderately 

 large. The blood-pressure rapidly 

 falls to zero. 



