STROPHANTHUS SARMENTOSUS : ITS PHARMACOLOGICAL ACTION. 



403 



Experiment LXXI. — Weight of rabbit, 1420 grams. '00 11 36 gram of extract 

 injected into the left jugular vein in four equal parts. Each injection = "0002 gram 

 per kilogram, and the total dose = 0'0008 gram per kilogram. The vagus was stimu- 

 lated at intervals before and after the administration of Strophanthus. 







Blood-pressure 













Substance 



in 



mm. oi Hg. 



Pulse- 



Respira- 



No. of 





Time. 



administered, 









rate per 



tions per 



Trac- 



Notes. 











and its Dose. 



Maxi- 

 mum. 



Mini- 

 mum. 



Aver- 

 age. 



10 sec. 



10 sec. 



ing. 





4.12 

















Left vagus cut. 



426.40 





78 



76 



77 



40 



8 





Pulse movements small. Respiration 

 waves large. 



427.30 

















Left vagus stimulated : secondary at 

 100 mm. ; marked slowing of heart's 

 rate and fall in blood-pressure, tem- 

 porarily. 



4.28.30 





76 



74 



75 



40 



8 







429.20 



Extract of 

















to 



Strophanthus, 

















4.29.30 



0'0002 gram per 

 kilogram, injected. 

















4.30.20 





86 



84 



85 



39 



8 





Pulse movements small. Respiration 

 waves large. 



4.31.20 





86 



84 



85 



40 



8 





Do. 



4.32.30 





84 



82 



83 



38 



8 





Do. 



4.33.30 





84 



82 



83 



40 



8 





Do. 



4.33.40 

















Left vagus stimulated : secondary at 

 100 mm.; heart slowed and blood- 

 pressure fell, temporarily.- 



4.34.30 





82 



82 



82 



40 



8 







4.37.30 





78 



78 



78 



39 



8 





Pulse waves small. Respiration waves 

 large. 



4.38.30 





78 



76 



75 



41 



8 





Do. 



4.39.10 



Extract of 















>- 



to 



Strophanthus, 

















4.39.20 



- 0002 gram per 

 kilogram, injected. 

















4.39.30 





84 



80 



82 



39 



8 







4.39.50 

















Left vagus stimulated : secondary at 

 100 mm. ; heart slowed and pressure 

 fell, temporarily. 



4.40.30 





86 



84 



85 



40 



8 







4.41.20 

















Left vagus stimulated : secondary at 

 100 mm. ; heart slowed and blood- 

 pressure fell, temporarily. 



4.41.50 





84 



82 



83 



40 



9 





Pulse waves small and irregular in size. 

 Respiration waves large. 



4.42.30 





84 



82 



83 



40 



9 





Do. 



4.46.30 





84 



84 



84 



40 



9 





Do. 



4.4650 

















Left vagus stimulated : secondary at 

 100 mm. ; heart slowed and blood- 

 pressure fell, temporarily. 



4.48.30 





74 



70 



72 



39 



8 







4.49.30 





68 



66 



67 



42 



9 





Pulse movements very small. Respira- 

 tion waves large. 



4.49.50 



Extract of 

















to 



Strophanthus, 

















4.50.0 



0-0002 gram per 

 kilogram, injected. 

















4.50.30 





76 



72 



74 



39 



9 





Each alternate pulse wave is larger. 

 Respiration waves large. 



4.51.30 





72 



70 



71 



40 



11 







4.52.30 





74 



72 



73 



43 



10 







