404 



SIR THOMAS R. FRASER AND MR ALISTER T. MACKENZIE ON 



Ex I w i •iment LXXI. — continued . 



Time. 



Substance 

 administered, 



and its Dose. 



Blood -pressure 

 in mm. of Hg. 



Pulse - 

 rate per 

 10 sec. 



45 



42 



40 



41 



40 

 38 



Respira- 

 tions per 

 10 sec. 



No. of 

 Trac- 

 ing. 



Notes. 



Maxi- 

 mum. 



Mini- 

 mum. 



72 

 74 



72 

 66 



64 



60 



8 



Aver- 

 age. 



75 

 76 



74 

 68 



68 

 62 



4.52.40 



4.53.30 

 4.54.30 



4.55.20 

 4.58.30 

 4.58.40 



to 

 4.58.50 



4.59.20 



5.0.10 



5.0.50 

 5.1.20 



Extract of 

 Strophanthus, 



0-0002 gram per 

 kilogram, injected. 



78 

 78 



76 



70 



72 



64 



74 



10 

 11 



11 

 10 



11 



10 





Left vagus stimulated : secondary at 

 100 mm. ; heart slowed and blood- 

 pressure fell, temporarily. 



Considerable variation in the size of the 

 pulse waves. Respiration waves large. 

 Do. 

 Do. 



Regular oscillations in the height of the 

 blood-pressure. Respiration waves 

 large. 



Left vagus stimulated : secondary at 

 100 mm. ; heart slowed and slight fall 

 of blood-pressure, temporarily. 



After this time, the blood -pressure fell 

 to zero almost, but rose spasmodi- 

 cally coincidentally with respiratory 

 convulsions. 



In this experiment, the extract of S. sarmentosus did not paralyse, nor to any 

 marked extent influence, the cardio-inhibitory function of the vagus. 



Experiment LXXII. — Weight of rabbit, 1660 grams. 0'005 gram of sulphate of 

 atropine in a single dose, and afterwards O'OOl gram of extract of S. sarmentosus in 

 five equal parts injected into the jugular vein. The vagus was stimulated from time 

 to time. 







Blood-pressure 











Time, 



Substance 

 administered, 

 and its dose. 



in mm. of Hg. 



Pulse- 

 rate per 

 10 sec. 



Respira- 

 tions per 

 10 sec. 



No. of 

 Trac- 

 ing. 



Notes. 



Maxi- 



Mini- 



Aver- 







mum. 



mum. 



age. 











3.18.20 

 3. 1 9.20 





78 



76 



77 



39 



ii 





Left vagus cut. 



Pulse movements small (less than 1 mm.). 

 Respiration waves large. 



3.20.10 

















Left vagus stimulated : secondary at 

 100 mm. ; heart slowed and blood- 



3.21.10 



to 

 3.21.20 



Sulphate of 

 Atropine, 



- 005 gram per 



kilogram, injected 



into left jugular 



vein. 















pressure fell temporarily. 



3.30.0 





80 



78 



79 



35 



10 







