406 SIR THOMAS R. FRASER AND MR ALISTER T. MACKENZIE ON 



Rxj leriment LXXII. — continued. 







Bio 



od-pressiire 













Substance 



in ] 



rim. of Hg. 



Pulse- 



Respira- 



No. of 





Time. 



administered, 









rate per 



tions per 



Trac- 



Notes. 











and its Dose. 



Maxi- 

 mum. 



Mini- 

 mum. 



64 



Aver- 

 age. 



10 sec. 



10 sec. 



ing. 





4.9.40 





78 



71 



31 



12 





Irregularities in the height of the blood- 



















pressure are frequent. Pulse move- 



















ments of 2 mm. occur. Respiration 



















waves large. 



4.14.30 





80 



68 



74 



31 



11 





Do. 



4.15.0 



Extract of 

















to 



Strophanthus, 

















4.15.10 



0'0002 gram per 

 kilogram, injected. 

















4.16.10 





80 



68 



74 



31 



11 





Do. 



4.16.50 



















Left vagus stimulated : secondary at 

 zero ; no effect. 



4.19.30 





74 



66 



70 



30 



11 







As at 4.9.40. 



4.19.40 



















Left vagus stimulated : secondary at 

 zero ; no effect. 



4.22.20 





66 



60 



63 



30 



12 









4.22.50 



















Left vagus stimulated : secondary at 

 zero ; no effect. 



4.25.0 





62 



56 



59 



30 



12 







As at 4.9.40. 



4.27.40 



















Left vagus stimulated : secondary at 



















zero ; no effect. 



4.30.0 





72 



64 



68 



29 



12 





Pulse movements are becoming smaller. 

 Respiration waves are large. Irregu- 

 larities of the blood-pressure continue. 



After this time, the pulse movements became indistinguishable, though the heart continued to beat feebly for 

 half an hour and the blood-pressure continued between 60 and 70 mm. 



In this experiment, although the vagus was paralysed by atropine, the first three 

 injections of Strophanthus were at once followed by a slight temporary rise in blood- 

 pressure. After the third injection, distinct irregularities in the height of the blood- 

 pressure occurred and continued till the end of the experiment. The pulse-rate fell a 

 little after the first injection of Strophanthus, increased a little after the second and 

 decreased during the rest of the experiment. The pulse movements became somewhat 

 larger after the first injection of Strophanthus ; after the third injection there was a 

 considerable increase in the size of the pulse waves, coincident with the occurrence of 

 irregularities in the blood-pressure and accompanied with slowing of the pulse-rate. 

 After the fourth injection, the pulse movements became very feeble. The respiratory 

 waves remained large throughout the experiment ; their rate fell a little after the 

 first injection of Strophanthus, and was slightly increased after the subsequent 

 infections. 



It would appear from these observations that paralysis of the inhibitory function of 

 the vagus nerve by atropine does not prevent the development of the usual effects of 

 S. sarmentosus in blood-pressure experiments, nor does it decidedly modify them. 



The foregoing blood-pressure experiments confirm the results of those experiments 



